The synthesis and metabolism of asymmetric dimethylarginine (ADMA)

被引：77

作者：

Leiper, JM ^{[1
]}

Vallance, P ^{[1
]}

机构：

[1] UCL, Ctr Clin Pharmacol & Therapeut, BHL Labs, Div Med, London WC1E 6JJ, England

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 2006年 / 62卷 / Suppl 1期

关键词：

asymmetric dimethylarginine; dimethylarginine dimethylaminohydrolase; protein arginine methyltransferase;

D O I：

10.1007/s00228-005-0013-y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Numerous reports have indicated that the plasma concentration of endogenously produced inhibitors of nitric oxide synthase are elevated in human disease states. In this review we discuss recent advances in our understanding of the enzymes responsible for the synthesis and metabolism of these inhibitors.

引用

页码：33 / 38

页数：6

共 62 条

[41] Involvement of accumulated endogenous NOS inhibitors and decreased NOS activity in the impaired neurogenic relaxation of the rabbit proximal urethra with ischaemia [J].

Masuda, H ;

Tsujii, T ;

Okuno, T ;

Kihara, K ;

Goto, M ;

Azuma, H .

BRITISH JOURNAL OF PHARMACOLOGY, 2001, 133 (01) :97-106

[42] Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension [J].

Matsuoka, H ;

Itoh, S ;

Kimoto, M ;

Kohno, K ;

Tamai, O ;

Wada, Y ;

Yasukawa, H ;

Iwami, G ;

Okuda, S ;

Imaizumi, T .

HYPERTENSION, 1997, 29 (01) :242-247

[43] STUDIES ON CATABOLISM OF NG-METHYLARGININE, NG,N'G-DIMETHYLARGININE AND NG,NG-DIMETHYLARGININE IN RABBIT [J].

MCDERMOTT, JR .

BIOCHEMICAL JOURNAL, 1976, 154 (01) :179-184

[44] PROTEIN TURNOVER IN SKELETAL MUSCLE .2. EFFECT OF STARVATION AND A PROTEIN-FREE DIET ON SYNTHESIS AND CATABOLISM OF SKELETAL MUSCLE PROTEINS IN COMPARISON TO LIVER [J].

MILLWARD, DJ .

CLINICAL SCIENCE, 1970, 39 (05) :591-+

[45] SYNTHESIS AND DEGRADATION OF METHYLATED PROTEINS OF MOUSE ORGANS - CORRELATION WITH PROTEIN-SYNTHESIS AND DEGRADATION [J].

MIYAKE, M ;

KAKIMOTO, Y .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1976, 25 (08) :885-896

[46] Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase [J].

Murray-Rust, J ;

Leiper, J ;

McAlister, M ;

Phelan, J ;

Tilley, S ;

Maria, JS ;

Vallance, P ;

McDonald, N .

NATURE STRUCTURAL BIOLOGY, 2001, 8 (08) :679-683

[47] METABOLISM OF NG,NG-DIMETHYLARGININE AND NG,N'G-DIMETHYLARGININE IN RATS [J].

OGAWA, T ;

KIMOTO, M ;

WATANABE, H ;

SASAOKA, K .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1987, 252 (02) :526-537

[48]

OGAWA T, 1989, J BIOL CHEM, V264, P10205

[49]

PAIK WK, 1968, J BIOL CHEM, V243, P2108

[50] VASCULAR ENDOTHELIAL-CELLS SYNTHESIZE NITRIC-OXIDE FROM L-ARGININE [J].

PALMER, RMJ ;

ASHTON, DS ;

MONCADA, S .

NATURE, 1988, 333 (6174) :664-666

← 1 2 3 4 5 6 7 →