The synthesis and metabolism of asymmetric dimethylarginine (ADMA)

被引：77

作者：

Leiper, JM ^{[1
]}

Vallance, P ^{[1
]}

机构：

[1] UCL, Ctr Clin Pharmacol & Therapeut, BHL Labs, Div Med, London WC1E 6JJ, England

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 2006年 / 62卷 / Suppl 1期

关键词：

asymmetric dimethylarginine; dimethylarginine dimethylaminohydrolase; protein arginine methyltransferase;

D O I：

10.1007/s00228-005-0013-y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Numerous reports have indicated that the plasma concentration of endogenously produced inhibitors of nitric oxide synthase are elevated in human disease states. In this review we discuss recent advances in our understanding of the enzymes responsible for the synthesis and metabolism of these inhibitors.

引用

页码：33 / 38

页数：6

共 62 条

[61] Elevated levels of plasma homocyst(e)ine and asymmetric dimethylarginine in elderly patients with stroke [J].

Yoo, JH ;

Lee, SC .

ATHEROSCLEROSIS, 2001, 158 (02) :425-430

[62] Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease:: a prospective study [J].

Zoccali, C ;

Bode-Böger, SM ;

Mallamaci, F ;

Benedetto, FA ;

Tripepi, G ;

Malatino, LS ;

Cataliotti, A ;

Bellanuova, I ;

Fermo, I ;

Frölich, JC ;

Böger, RH .

LANCET, 2001, 358 (9299) :2113-2117

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