Growth and Differentiation Effects of Homer3 on a Leukemia Cell Line

被引：10

作者：

Li, Zheng ^{[1
]}

Qiu, Hui-Ying ^{[1
]}

Jiao, Yang ^{[2
]}

Cen, Jian-Nong ^{[1
]}

Fu, Chun-Mei ^{[1
]}

Hu, Shao-Yan ^{[3
]}

Zhu, Ming-Qing ^{[1
]}

Wu, De-Pei ^{[1
]}

Qi, Xiao-Fei ^{[1
,4
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Minist Hlth, Leukemia Res Div,Jiangsu Inst Hematol,Key Lab Thr, Suzhou, Peoples R China

[2] Soochow Univ, Coll Med, Sch Radiat Med & Protect, Suzhou, Peoples R China

[3] Soochow Univ, Childrens Hosp, Dept Hematol, Suzhou, Peoples R China

[4] Soochow Univ, Affiliated Hosp 1, Dept Urol, Suzhou, Peoples R China

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2013年 / 14卷 / 04期

关键词：

Homer3; leukemia cell line; cell proliferation; apoptosis; differentiation; ACUTE MYELOID-LEUKEMIA; AML; EXPRESSION; PROGNOSIS; GENE; MICROARRAY; CYTOGENETICS; IMPACT;

D O I：

10.7314/APJCP.2013.14.4.2525

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The Homer protein family, also known as the family of cytoplasmic scaffolding proteins, which include three subtypes (Homer1, Homer2, Homer3). Homer3 can regulate transcription and play a very important role in the differentiation and development for some tissues (e. g. muscle and nervous systems). The current studies showed that Homer3 abnormal expression changes in acute myeloid leukemia (AML). Forced expression of Homer3 in transfected K562 cells inhibited proliferation, influenced the cell cycle profile, affected apoptosis induced by As2O3 through inhibition of Bcl2 expression, and also promoted cell differentiation induced by 12-O-tetra decanoylphorbol-acetate (TPA). These results showed that Homer3 is a novel gene which plays a certain role in the occurrence and development of AML.

引用

页码：2525 / 2528

页数：4

共 21 条

[1]

Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: activation of caspases and down-regulation of Bcl-2 protein [J].