Autoimmunity to human heat shock protein 60, Chlamydia pneumoniae infection, and inflammation in predicting coronary risk

被引:75
作者
Huittinen, T
Leinonen, M
Tenkanen, L
Mänttäri, M
Virkkunen, H
Pitkänen, T
Wahlström, E
Palosuo, T
Manninen, V
Saikku, P
机构
[1] Natl Publ Hlth Inst, FIN-90101 Oulu, Finland
[2] Natl Publ Hlth Inst, Helsinki, Finland
[3] Univ Helsinki, Cent Hosp, Dept Med, Helsinki, Finland
[4] Univ Oulu, Dept Med Microbiol, Oulu, Finland
关键词
atherosclerosis; risk factors; autoimmunity; heat shock protein; Chlamydia pneumoniae;
D O I
10.1161/hq0302.104512
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Heat shock protein 60 (Hsp60) and Chlamydia pneumoniae infection have both been associated with cardiovascular diseases, Our aim was to study the role of Hsp60 antibodies as coronary risk predictors and their association with C pneumoniae infection and inflammation. This was a prospective, nested, case-control study. The cases consisted of 239 middle-aged Finnish men who developed myocardial infarction or coronary death during the follow-up. Baseline levels of IgA and IgG antibodies to human-specific and C pneumoniae-specific Hsp60 were measured by enzyme immunoassay. Human Hsp60 IgA, but not IgG or C pneumoniae Hsp60, antibodies were a significant risk factor for coronary events (odds ratio 2.0, 95% CI 1.1 to 3.6, when the fourth and first quartiles are compared). When an elevated human Hsp60 IgA antibody level (above the second quartile) was present simultaneously with a high C pneumoniae IgA antibody level (the third quartile) and an elevated C-reactive protein level (the second quartile), compared with all factors at low levels, the risk was 7.0 (95 % Cl 2.6 to 19.1) without adjustment and 5.0 (95 % CI 1.8 to 14.2) when adjustment was made for age and smoking. In conclusion, an elevated human Hsp60 IgA antibody level was a risk factor for coronary events, especially when it was present together with C pneumoniae infection and inflammation.
引用
收藏
页码:431 / 437
页数:7
相关论文
共 38 条
[1]   Association between antibodies to heat shock protein 65 and coronary atherosclerosis - Possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk [J].
Birnie, DH ;
Holme, ER ;
McKay, IC ;
Hood, S ;
McColl, KEL ;
Hillis, WS .
EUROPEAN HEART JOURNAL, 1998, 19 (03) :387-394
[2]   Chronic infections and coronary heart disease: is there a link? [J].
Danesh, J ;
Collins, R ;
Peto, R .
LANCET, 1997, 350 (9075) :430-436
[3]   Chlamydia pneumoniae IgG titres and coronary heart disease:: prospective study and meta-analysis [J].
Danesh, J ;
Whincup, P ;
Walker, M ;
Lennon, L ;
Thomson, A ;
Appleby, P ;
Wong, YK ;
Bernardes-Silva, M ;
Ward, M .
BRITISH MEDICAL JOURNAL, 2000, 321 (7255) :208-212
[4]   Rabbit model for Chlamydia pneumoniae infection [J].
Fong, IW ;
Chiu, B ;
Viira, E ;
Fong, MW ;
Jang, D ;
Mahony, J .
JOURNAL OF CLINICAL MICROBIOLOGY, 1997, 35 (01) :48-52
[5]   HELSINKI HEART-STUDY - PRIMARY-PREVENTION TRIAL WITH GEMFIBROZIL IN MIDDLE-AGED MEN WITH DYSLIPIDEMIA - SAFETY OF TREATMENT, CHANGES IN RISK-FACTORS, AND INCIDENCE OF CORONARY HEART-DISEASE [J].
FRICK, MH ;
ELO, O ;
HAAPA, K ;
HEINONEN, OP ;
HEINSALMI, P ;
HELO, P ;
HUTTUNEN, JK ;
KAITANIEMI, P ;
KOSKINEN, P ;
MANNINEN, V ;
MAENPAA, H ;
MALKONEN, M ;
MANTTARI, M ;
NOROLA, S ;
PASTERNACK, A ;
PIKKARAINEN, J ;
ROMO, M ;
SJOBLOM, T ;
NIKKILA, EA .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (20) :1237-1245
[6]   Enhanced fatty streak formation in C57BL/6J mice by immunization with heat shock protein-65 [J].
George, J ;
Shoenfeld, Y ;
Afek, A ;
Gilburd, B ;
Keren, P ;
Shaish, A ;
Kopolovic, J ;
Wick, G ;
Harats, D .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (03) :505-510
[7]   THE HELSINKI-HEART-STUDY - CORONARY HEART-DISEASE INCIDENCE DURING AN EXTENDED FOLLOW-UP [J].
HEINONEN, OP ;
HUTTUNEN, JK ;
MANNINEN, V ;
MANTTARI, M ;
KOSKINEN, P ;
TENKANEN, L ;
FRICK, MH .
JOURNAL OF INTERNAL MEDICINE, 1994, 235 (01) :41-49
[8]   Changes of serum antibodies to heat-shock protein 65 in coronary heart disease and acute myocardial infarction [J].
Hoppichler, F ;
Lechleitner, M ;
Traweger, C ;
Schett, G ;
Dzien, A ;
Sturm, W ;
Xu, QB .
ATHEROSCLEROSIS, 1996, 126 (02) :333-338
[9]   Host immune response to Chlamydia pneumoniae heat shock protein 60 is associated with asthma [J].
Huittinen, T ;
Hahn, D ;
Anttila, T ;
Wahlström, E ;
Saikku, P ;
Leinonen, M .
EUROPEAN RESPIRATORY JOURNAL, 2001, 17 (06) :1078-1082
[10]   IMPORTANCE OF SMOKING FOR CHLAMYDIA-PNEUMONIAE SEROPOSITIVITY [J].
KARVONEN, M ;
TUOMILEHTO, J ;
PITKANIEMI, J ;
NAUKKARINEN, A ;
SAIKKU, P .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1994, 23 (06) :1315-1321