Optical resolution of 2-(3-indolyl)propionic acid with Mucor java']javanicus and α-chymotrypsin

被引：5

作者：

Kato, K ^{[1
]}

Gong, Y ^{[1
]}

Tanaka, S ^{[1
]}

Katayama, M ^{[1
]}

Kimoto, H ^{[1
]}

机构：

[1] Natl Ind Res Inst Nagoya, Dept Chem, Kita Ku, Nagoya, Aichi 4628510, Japan

来源：

BIOTECHNOLOGY LETTERS | 1999年 / 21卷 / 05期

关键词：

alpha-chymotrypsin; Mucor [!text type='java']java[!/text]nicus; optical resolution; 2-(3-indolyl)propionic acid;

D O I：

10.1023/A:1005550806687

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Resolution of 2-(3-indolyl)propionic acid was achieved via biocatalytic hydrolysis of its chloroethyl ester. Of the enzymes tested, Mucor javanicus lipase (R selectivity) and alpha-chymotrypsin (S selectivity) had high reactivity and enantioselectivity (E value > 50). Neither enzyme showed enantioselectivity (E value = 1) for 2-phenylpropionic acid.

引用

页码：457 / 461

页数：5

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