Oxidized LDL and expression of monocyte adhesion molecules

被引：37

作者：

Kita, T ^{[1
]}

Kume, N ^{[1
]}

Ishii, K ^{[1
]}

Horiuchi, H ^{[1
]}

Arai, H ^{[1
]}

Yokode, M ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Geriatr Med, Kaky Ku, Kyoto 60101, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 1999年 / 45卷 / 2-3期

关键词：

oxidized LDL; monocyte adhesion molecules; lysophosphatidylcholine; Lox-1;

D O I：

10.1016/S0168-8227(99)00041-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Accumulation of substantial numbers of monocyte/macrophages, as well as activated T lymphocytes, in focal areas of arterial intima appears to be a hallmark of atherogenesis. Our report demonstrated that lysophosphatidylcholine (lyso-PC), a polar phospholipid component that is increased in atherogenic lipoproteins, such as oxidized LDL and remnants lipoproteins in diabetic and type III hyperlipidemic patients, can upregulate adhesion molecules for monocytes and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF-A and B chains. Recently we identified the novel receptor for oxidized LDL, named Lox-1. Therefore: in this paper we summarize the importance of the interaction between oxidized LDL and its receptor, LOX-I in terms of early stage of atherogenesis. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：123 / 126

页数：4

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