The effects of naloxone on flavor-calorie preference learning indicate involvement of opioid reward systems

被引:18
作者
Mehiel, R
机构
[1] Department of Psychology, Shippensburg University, Shippensburg, PA 17257-2299
关键词
D O I
10.1007/BF03395176
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Four experiments investigated the effects of the opioid antagonist naloxone hydrochloride on learning and expression of preferences for flavors paired with calories from dextrose or ethanol. Experiments 1 through 3 showed that naloxone eliminated a dextrose-paired flavor preference in two-bottle and one-bottle tests. When naloxone was paired with flavored dextrose in conditioning trials, no preference for the naloxonepaired flavor over the saccharin-paired flavor emerged. Naloxone also eliminated the preference for an ethanol-paired flavor over a saccharin-paired flavor in postconditioning tests. In Experiment 4 shock-induced freezing was used as a probe for conditioned opioidergic activity brought on by tasting a flavor that had been paired with dextrose. Rats froze less after tasting the dextrose-paired flavor than after tasting a saccharin-paired flavor. These results are discussed as evidence for involvement of central opioid reward systems in flavor-calorie learning.
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页码:435 / 450
页数:16
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