Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease

被引：81

作者：

Zhang, RM ^{[1
]}

Durkin, JP ^{[1
]}

Windsor, WT ^{[1
]}

机构：

[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(02)00102-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Truncation and substitution SAR studies of azapeptide-based inhibitors of the Hepatitis C virus (HCV) NS3 serine protease have been performed. These azapeptides were designed from the HCV polyprotein's NS5A-NS5B trans cleavage junction and contained an azaamino acid residue at the P1 position. These azapeptides exhibited predominantly non-acylating, competitive inhibition, contrary to classical azapeptides. (C), 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1005 / 1008

页数：4

共 27 条

[1] TO C OR NOT TO C - THESE ARE THE QUESTIONS [J].