Crystalline Calcium Alendronate Obtained by Octacalcium Phosphate Digestion: A New Chance for Local Treatment of Bone Loss Diseases?

被引：28

作者：

Boanini, Elisa ^{[1
]}

Torricelli, Paola ^{[2
]}

Gazzano, Massimo ^{[3
]}

Fini, Milena ^{[2
]}

Bigi, Adriana ^{[1
]}

机构：

[1] Univ Bologna, Dept Chem Giacomo Ciamician, I-40126 Bologna, Italy

[2] Rizzoli Orthopaed Inst, Codivilla Putti Res Inst, Preclin & Surg Studies Lab, Bologna, Italy

[3] ISOF CNR, Inst Organ Synth & Photoreact, Bologna, Italy

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 33期

关键词：

octacalcium phosphate; bisphosphonate; in vitro co-cultures; OSTEOBLAST-LIKE CELLS; IN-VITRO; HYDROXYAPATITE NANOCOMPOSITES; ZOLEDRONIC ACID; TISSUE CULTURE; BISPHOSPHONATES; EXPRESSION; RESORPTION; MODEL; DISSOLUTION;

D O I：

10.1002/adma.201301129

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Octacalcium phosphate (OCP) interaction with alendronate (AL) solution results in the complete digestion of OCP: calcium ion is recruited by the bisphosphonate to yield quantitative precipitation of crystalline calcium alendronate monohydrate. This compound improves osteoblast differentiation and inhibits osteoclast proliferation and activity, both alone and, even more, in combination with OCP. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4605 / 4611

页数：7

共 37 条

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Biofunctional alendronate-Hydroxyapatite thin films deposited by Matrix Assisted Pulsed Laser Evaporation [J].