Hepatitis C Viral Kinetics The Past, Present, and Future

被引：21

作者：

Chatterjee, Anushree ^{[1
,2
]}

Smith, Patrick F. ^{[3
]}

Perelson, Alan S. ^{[1
]}

机构：

[1] Los Alamos Natl Lab, Theoret Biol & Biophys, Los Alamos, NM 87545 USA

[2] Los Alamos Natl Lab, Ctr Nonlinear Studies, Los Alamos, NM 87545 USA

[3] Roche, Clin Pharmacol Pharma Res & Early Dev, Nutley, NJ USA

来源：

CLINICS IN LIVER DISEASE | 2013年 / 17卷 / 01期

关键词：

Mathematical modeling; Viral kinetics; Direct-acting antiviral agents; Protease inhibitors; Hepatitis C virus; DYNAMICS IN-VIVO; POLYMERASE INHIBITOR; ANTIVIRAL ACTIVITY; PROTEASE INHIBITORS; VIRUS-REPLICATION; TREATMENT-NAIVE; NONNUCLEOSIDE POLYMERASE; RESISTANCE MUTATIONS; ALPHA-INTERFERON; WILD-TYPE;

D O I：

10.1016/j.cld.2012.09.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Mathematical modeling of hepatitis C viral kinetics has been an important tool in understanding hepatitis C virus (HCV) infection dynamics and in estimating crucial in vivo parameters characterizing the effectiveness of HCV therapy. Because of the introduction of direct-acting antiviral agents, there is a need to extend previous models so as to understand, characterize, and compare various new HCV treatment regimens. Here we review recent modeling efforts in this direction.

引用

页码：13 / +

页数：15

共 70 条

[1] Sustained viral response to interferon and ribavirin in liver transplant recipients with recurrent hepatitis C [J].

Abdelmalek, MF ;

Firpi, RJ ;

Soldevila-Pico, C ;

Reed, AI ;

Hemming, AW ;

Liu, C ;

Crawford, JM ;

Davis, GL ;

Nelson, DR .

LIVER TRANSPLANTATION, 2004, 10 (02) :199-207

[2] A Multi-Variant, Viral Dynamic Model of Genotype 1 HCV to Assess the in vivo Evolution of Protease-Inhibitor Resistant Variants [J].

Adiwijaya, Bambang S. ;

Herrmann, Eva ;

Hare, Brian ;

Kieffer, Tara ;

Lin, Chao ;

Kwong, Ann D. ;

Garg, Varun ;

Randle, John C. R. ;

Sarrazin, Christoph ;

Zeuzem, Stefan ;

Caron, Paul R. .

PLOS COMPUTATIONAL BIOLOGY, 2010, 6 (04)

[3]

Adiwijaya BS, 2009, ANTIVIR THER, V14, P591

[4] Silibinin and Related Compounds Are Direct Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase [J].

Ahmed-Belkacem, Abdelhakim ;

Ahnou, Nazim ;

Barbotte, Laetitia ;

Wychowski, Czeslaw ;

Pallier, Coralie ;

Brillet, Rozenn ;

Pohl, Ralf-Torsten ;

Pawlotsky, Jean-Michel .

GASTROENTEROLOGY, 2010, 138 (03) :1112-1122

[5] Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3•4A protease inhibitors in treatment-naive subjects [J].

Bartels, Doug J. ;

Zhou, Yi ;

Zhang, Eileen Z. ;

Marcial, Michelle ;

Byrn, Randal A. ;

Pfeiffer, Thomas ;

Tigges, Ann M. ;

Adiwijaya, Bambang S. ;

Lin, Chao ;

Kwong, Ann D. ;

Kieffer, Tara L. .

JOURNAL OF INFECTIOUS DISEASES, 2008, 198 (06) :800-807

[6] Pharmacokinetic-Pharmacodynamic Modeling of Alpha Interferon Response Induced by a Toll-Like 7 Receptor Agonist in Mice [J].

Benson, Neil ;

de Jongh, Joost ;

Duckworth, Jonathan D. ;

Jones, Hannah M. ;

Pertinez, Henry E. ;

Rawal, Jaiessh K. ;

van Steeg, Tamara J. ;

Van der Graaf, Piet H. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (03) :1179-1185

[7] Second-wave Protease Inhibitors: Choosing an Heir [J].

Ciesek, Sandra ;

von Hahn, Thomas ;

Manns, Michael P. .

CLINICS IN LIVER DISEASE, 2011, 15 (03) :597-+

[8] DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A [J].

Coelmont, Lotte ;

Hanoulle, Xavier ;

Chatterji, Udayan ;

Berger, Carola ;

Snoeck, Joke ;

Bobardt, Michael ;

Lim, Precious ;

Vliegen, Inge ;

Paeshuyse, Jan ;

Vuagniaux, Gregoire ;

Vandamme, Anne-Mieke ;

Bartenschlager, Ralf ;

Gallay, Philippe ;

Lippens, Guy ;

Neyts, Johan .

PLOS ONE, 2010, 5 (10)

[9] Modeling hepatitis C virus dynamics: Liver regeneration and critical drug efficacy [J].

Dahari, Harel ;

Lo, Arthur ;

Ribeiro, Ruy M. ;

Perelson, Alan S. .

JOURNAL OF THEORETICAL BIOLOGY, 2007, 247 (02) :371-381

[10] Mathematical modeling of subgenomic hepatitis C virus replication in Huh-7 cells [J].

Dahari, Harel ;

Ribeiro, Ruy M. ;

Rice, Charles M. ;

Perelson, Alan S. .

JOURNAL OF VIROLOGY, 2007, 81 (02) :750-760

← 1 2 3 4 5 6 7 →