Synthesis and characterization of selenium-chondroitin sulfate nanoparticles

被引：56

作者：

Han, Jing ^{[1
]}

Guo, Xiong ^{[1
]}

Lei, Yanxia ^{[1
]}

Dennis, Bannel S. ^{[1
]}

Wu, Shixun ^{[1
]}

Wu, Cuiyan ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Key Lab Environm & Gene Related Dis, Key Lab Trace Elements & Endem Dis, Fac Publ Hlth,Coll Med,Minist Educ,Minist Hlth, Xian 710061, Shaanxi, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2012年 / 90卷 / 01期

基金：

高等学校博士学科点专项科研基金;

关键词：

Nanoparticle; Selenium-chondroitin sulfate; Chondrocytes; Kashin-Beck disease; Osteoarthritis; KASHIN-BECK-DISEASE; ELEMENTAL SELENIUM; CARTILAGE; OSTEOARTHRITIS; EXPRESSION; CHITOSANS; CHITINS; BONE;

D O I：

10.1016/j.carbpol.2012.04.068

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

A novel selenium-chondroitin sulfate (SeCS) was synthesized by ultrasonic and dialysis method. With characterization by FTIR, XRD and TEM, the SeCS was found to form nanoparticles in distilled water through a self-aggregation progress. The SeCS nanoparticles had sizes between 30 and 200 nm with selenium entrapment efficiency of about 10.1%. The anti-toxin capacity of SeCS nanoparticles was demonstrated through MTT and apoptosis assays in vitro. Results indicated that the SeCS was less cytotoxic to chondrocytes than sodium selenite. In particular, the SeCS could obviously alleviate chondrocyte apoptosis induced by T-2 toxin compared to chondroitin sulfate. These results thus represent an advanced understanding of the properties of SeCS nanoparticles and demonstrate their exciting potential applications in therapy of Kashin-Beck disease (KBD) and osteoarthritis. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：122 / 126

页数：5

共 20 条

[1]

Effect of the counterion behavior on the frictional-compressive properties of chondroitin sulfate solutions [J].