Role of Lipotoxicity in Endothelial Dysfunction

被引：118

作者：

Kim, Jeong-a ^{[3
,4
]}

Montagnani, Monica ^{[2
]}

Chandrasekran, Sruti ^{[1
]}

Quon, Michael J. ^{[1
]}

机构：

[1] Univ Maryland, Div Endocrinol Diabet & Nutr, Dept Med, Baltimore, MD 21201 USA

[2] Univ Aldo Moro Bari, Dept Biomed Sci & Human Oncol, Pharmacol Sect, Policlin Bari, I-70124 Bari, Italy

[3] Univ Alabama Birmingham, Dept Cell Biol, Birmingham, AL 35294 USA

[4] Univ Alabama Birmingham, UAB Comprehens Diabet Ctr, Dept Med, Div Endocrinol Diabet & Metab, Birmingham, AL 35294 USA

来源：

HEART FAILURE CLINICS | 2012年 / 8卷 / 04期

关键词：

Lipotoxicity; Endothelial dysfunction; Metabolic disorders; Cardiovascular disease; LOW-DENSITY-LIPOPROTEIN; NITRIC-OXIDE SYNTHASE; ENDOPLASMIC-RETICULUM STRESS; FREE FATTY-ACIDS; INSULIN-RECEPTOR SUBSTRATE-1; PROTEIN-KINASE-C; TYPE-2; DIABETES-MELLITUS; CORONARY-HEART-DISEASE; PPAR-ALPHA ACTIVATORS; ADHESION MOLECULE-1 EXPRESSION;

D O I：

10.1016/j.hfc.2012.06.012

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Vascular endothelial dysfunction is determined by both genetic and environmental factors that cause decreased bioavailability of the vasodilator nitric oxide. This is a hallmark of atherosclerosis, hypertension, and coronary heart disease, which are major complications of metabolic disorders, including diabetes and obesity. Several therapeutic interventions, including changes in lifestyle as well as pharmacologic treatments, are useful for improving endothelial dysfunction in the face of lipotoxicity. This review discusses the current understanding of molecular and physiologic mechanisms underlying lipotoxicity-mediated endothelial dysfunction as well as relevant therapeutic approaches to ameliorate dyslipidemia and consequent endothelial dysfunction that have the potential to improve cardiovascular and metabolic outcomes.

引用

页码：589 / +

页数：21

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