Haloferax volcanii PitA:: an example of functional interaction between the Pfam chlorite dismutase and antibiotic biosynthesis monooxygenase families?

被引：31

作者：

Bab-Dinitz, E

Shmuely, H

Maupin-Furlow, J

Eichler, J

Shaanan, B ^{[1
]}

机构：

[1] Ben Gurion Univ Negev, Dept Life Sci, IL-84105 Beer Sheva, Israel

[2] Univ Florida, Dept Microbiol & Cell Sci, Gainesville, FL 32611 USA

来源：

BIOINFORMATICS | 2006年 / 22卷 / 06期

基金：

美国国家卫生研究院; 以色列科学基金会;

关键词：

D O I：

10.1093/bioinformatics/btk043

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A curious fusion between chlorite dismutase-like and antibiotic biosynthesis monooxygenase-like domains within a single open reading frame has been revealed by both sequence homology and structural modeling in Haloferax volcanii PitA and its homologues in other halophilic archaea. While this fusion may reflect an environmental adaptation to life in hypersaline environments and hence one specific to haloarchaea, PitA and its homologues may represent a paradigm of biologically-relevant interplay between these two distinct activities in accordance with the Rosetta Stone approach.

引用

页码：671 / 675

页数：5

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