Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing

被引：67

作者：

Abril, Maria K. ^{[1
]}

Barnett, Adam S. ^{[1
]}

Wegermann, Kara ^{[1
]}

Fountain, Eric ^{[1
]}

Strand, Andrew ^{[2
]}

Heyman, Benjamin M. ^{[3
]}

Blough, Britton A. ^{[4
]}

Swaminathan, Aparna C. ^{[4
]}

Sharma-Kuinkel, Batu ^{[2
]}

Ruffin, Felicia ^{[2
]}

Alexander, Barbara D. ^{[2
]}

McCall, Chad M. ^{[5
]}

Costa, Sylvia F. ^{[2
]}

Arcasoy, Murat O. ^{[3
]}

Hong, David K. ^{[6
]}

Blauwkamp, Timothy A. ^{[6
]}

Kertesz, Michael ^{[6
]}

Fowler, Vance G., Jr. ^{[2
]}

Kraft, Bryan D. ^{[4
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Div Infect Dis, Durham, NC USA

[3] Duke Univ, Med Ctr, Div Hematol, Durham, NC USA

[4] Duke Univ, Med Ctr, Div Pulm Allergy & Crit Care Med, Durham, NC USA

[5] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

[6] Karius Inc, Menlo Pk, CA USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2016年 / 3卷 / 03期

基金：

美国国家卫生研究院;

关键词：

high-throughput nucleotide sequencing; microbiological techniques; sepsis/diagnosis; INFECTION; THERAPY; MENINGITIS; SURVIVAL; SHOCK;

D O I：

10.1093/ofid/ofw144

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report the case of a 60-year-old man with septic shock due to Capnocytophaga canimorsus that was diagnosed in 24 hours by a novel whole-genome next-generation sequencing assay. This technology shows great promise in identifying fastidious pathogens, and, if validated, it has profound implications for infectious disease diagnosis.

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页数：4

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