A convenient procedure for the reduction of S-(+)-silyl serine methyl ester to chiral serinol derivatives

被引：23

作者：

Novachek, KA ^{[1
]}

Meyers, AI ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT CHEM,FT COLLINS,CO 80523

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 11期

关键词：

D O I：

10.1016/0040-4039(96)00164-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reduction of S-(+)-serine methyl ester silyl ether with NaBH4 followed by acidic workup produced the chiral serinol derivatives with minimum racemization. Addition of MeMgBr gave the functionalized amine diol in high yield with no racemization.

引用

页码：1743 / 1746

页数：4

共 24 条

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