Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA

被引：167

作者：

Rana, TM

Jeang, KT

机构：

[1] Robert Wood Johnson Rutgers Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA

[2] NIH, Mol Microbiol Lab, Bethesda, MD 20892 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1999年 / 365卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1006/abbi.1999.1206

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HIV-1 trans-activator of transcription (Tat) is an unusual transcriptional activator in being an RNA-binding protein rather than a DNA-binding protein. Recent findings have greatly advanced our understanding of the transcriptional function(s) of this protein. Here we review how Tat interacts with trans-activation responsive RNA and how this interaction contributes to transcription. We discuss the biological implications of recent studies showing an association of Tat with cellular kinases(s) and protein acetylases. Evidence for nontranscriptional activities of the Tat protein is also summarized. (C) 1999 Academic Press.

引用

收藏

页码：175 / 185

页数：11

相关论文

共 95 条

[1] Structure of HIV-1 TAB RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge [J].

AboulEla, F ;

Karn, J ;

Varani, G .

NUCLEIC ACIDS RESEARCH, 1996, 24 (20) :3974-3981

[2] THE STRUCTURE OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TAR RNA REVEALS PRINCIPLES OF RNA RECOGNITION BY TAT PROTEIN [J].

ABOULELA, F ;

KARN, J ;

VARANI, G .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 253 (02) :313-332

[3] HIV-1 Tat protein mimicry of chemokines [J].

Albini, A ;

Ferrini, S ;

Benelli, R ;

Sforzini, S ;

Giunciuglio, D ;

Aluigi, MG ;

Proudfoot, AEI ;

Alouani, S ;

Wells, TNC ;

Mariani, G ;

Rabin, RL ;

Farber, JM ;

Noonan, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13153-13158

[4] STRUCTURAL STUDIES OF HIV-1 TAT PROTEIN [J].

BAYER, P ;

KRAFT, M ;

EJCHART, A ;

WESTENDORP, M ;

FRANK, R ;

ROSCH, P .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 247 (04) :529-535

[5] Activation of integrated provirus requires histone acetyltransferase - p300 AND P/CAF are coactivators for HIV-1 Tat [J].

Benkirane, M ;

Chun, RF ;

Xiao, H ;

Ogryzko, VV ;

Howard, BH ;

Nakatani, Y ;

Jeang, KT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (38) :24898-24905

[6] DETAILED MUTATIONAL ANALYSIS OF TAR RNA - CRITICAL SPACING BETWEEN THE BULGE AND LOOP RECOGNITION DOMAINS [J].

BERKHOUT, B ;

JEANG, KT .

NUCLEIC ACIDS RESEARCH, 1991, 19 (22) :6169-6176

[7] TAT TRANS-ACTIVATES THE HUMAN IMMUNODEFICIENCY VIRUS THROUGH A NASCENT RNA TARGET [J].

BERKHOUT, B ;

SILVERMAN, RH ;

JEANG, KT .

CELL, 1989, 59 (02) :273-282

[8] FUNCTIONAL ROLES FOR THE TATA PROMOTER AND ENHANCERS IN BASAL AND TAT-INDUCED EXPRESSION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 LONG TERMINAL REPEAT [J].

BERKHOUT, B ;

JEANG, KT .

JOURNAL OF VIROLOGY, 1992, 66 (01) :139-149

[9] TAR-INDEPENDENT ACTIVATION OF THE HIV-1-LTR - EVIDENCE THAT TAT REQUIRES SPECIFIC REGIONS OF THE PROMOTER [J].

BERKHOUT, B ;

GATIGNOL, A ;

RABSON, AB ;

JEANG, KT .

CELL, 1990, 62 (04) :757-767

[10] Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat [J].

Bieniasz, PD ;

Grdina, TA ;

Bogerd, HP ;

Cullen, BR .

EMBO JOURNAL, 1998, 17 (23) :7056-7065

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