Stachyflin and acetylstachyflin, novel anti-influenza A virus substances, produced by Stachybotrys sp RF-7260 I.: Isolation, structure elucidation and biological activities

被引：62

作者：

Minagawa, K ^{[1
]}

Kouzuki, S ^{[1
]}

Yoshimoto, J ^{[1
]}

Kawamura, Y ^{[1
]}

Tani, H ^{[1
]}

Iwata, T ^{[1
]}

Terui, Y ^{[1
]}

Nakai, H ^{[1
]}

Yagi, S ^{[1
]}

Hattori, N ^{[1
]}

Fujiwara, T ^{[1
]}

Kamigauchi, T ^{[1
]}

机构：

[1] Shionogi & Co Ltd, Shionogi Res Labs, Fukushima Ku, Osaka 5530002, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2002年 / 55卷 / 02期

关键词：

D O I：

10.7164/antibiotics.55.155

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two novel compounds, stachyflin and acetylstachyflin, have been isolated by solid-state fermentation of Stachybotrys sp. RF-7260. The structures of both metabolites, determined by detailed NMR analyses and X-ray crystallographic analysis, are novel with a pentacyclic moiety including cis-fused decalin. The absolute stereochemistry of stachyflins was determined by circular dichroism analysis. Stachyflin showed antiviral activity against influenza A virus (H1N1) in vitro with an IC50 value of 0.003 mum. Acetylstachyflin was about 77-fold less active than stachyflin.

引用

页码：155 / 164

页数：10

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