Effect of tonifying liver and kidney-essence herbs on expression of Nogo-A and p75NTR in cerebral ischemic stroke rats model

被引:3
作者
Yan, Yongmei [2 ]
Li, Tianhao [3 ]
Liu, Li [1 ]
Zhou, Haizhe [1 ]
机构
[1] Shaanxi Univ Tradit Med, Chinese Med Dept Internal Med, Xianyang 712000, Shaanxi, Peoples R China
[2] Shaanxi Univ Tradit Med Hosp, Dept Encephalopathy, Xianyang 712000, Shaanxi, Peoples R China
[3] Shaanxi Univ Tradit Med, Affiliated Hosp 2, Dept Pneumol, Xianyang 712000, Shaanxi, Peoples R China
关键词
Stroke; Invigorating the spleen; Nourishing the liver; Nerve Growth Factors; Receptor; nerve growth factor; MYELIN-ASSOCIATED GLYCOPROTEIN; SPINAL-CORD-INJURY; NEURITE OUTGROWTH; RECEPTOR; INHIBITOR; INTERACTS; LINGO-1; LIGAND;
D O I
10.1016/S0254-6272(13)60089-8
中图分类号
R [医药、卫生];
学科分类号
100218 [急诊医学];
摘要
OBJECTIVE: To observe the effect of tonifying liver and kidney-essence herbs on expression of a nerve regeneration inhibitor, Nogo for neuron A (Nogo-A), and its associated signaling molecule, low-affinity neurotrophin receptor p75 (p75(NTR)), in rats with cerebral ischemic stroke (CIS), with the aim of exploring the possible mechanism of tonifying liver and kidney-essence herbs in recovery following injury to the central nervous system. METHODS: A cerebral ischemic stroke model in SD rats was established with the suture-occlusion method. Successful model rats were divided into placebo and herb groups at random; sham-operated and control groups were set up simultaneously. Each of these groups was divided into six subgroups at random. Expression of Nogo-A and p75(NTR) was evaluated with immunofluorescence microscopy at days 3, and weeks1, 2, 3, 4 and 8 after administration. RESULTS: Tonifying liver and kidney-essence herbs suppressed the expression of Nogo-A and p75NTR (P<0.05 and P<0.01, respectively). CONCLUSION: Suppressing the expression of Nogo-A and p75(NTR) is possibly one of the mechanisms underlying the ability of tonifying liver and kidney-essence herbs to promote recovery of the injured central nervous system. (C) 2012 JTCM. All rights reserved.
引用
收藏
页码:664 / 668
页数:5
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