Prolylcarboxypeptidase: A cardioprotective enzyme

Prolycarboxypeptidase (PRCP) is involved in regulating the blood flow through active tissues in order to preserve the internal environment. The expression of PRCP in tissues is determined by a number of pharmacological stimuli such as glucocorticoids and a combination of dexamethasone plus the mu-opioid receptor agonise [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate. PRCP is all enzyme which is associated with preeclampsia, rheumatoid arthritis, and tonsillitis. The interplay between inward cellular signalling required for induced and basal transcription, and PRCP expression have not been mechanistically characterized. Molecules modulated by PROP include angiotensin II (Ang II), angiotensin III (Ang III), alpha-MSH, and prekallikrein (PK), demonstrating its cardiovascular protective role. In addition to regulating vascular tone, PROP may modulate proliferation, cell migration, and angiogenesis through regulating angiotensin molecules - and bradykinin - induced endothelium activation. The anti-hypertensive and proinflammatory properties of PRCP implicate that this enzyme may well be all accessible target for anti-inflammatory therapy. Published by Elsevier Ltd.