Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor

被引：39

作者：

Frampton, Dan ^{[1
]}

Schwenzer, Hagen ^{[1
]}

Marino, Gabriele ^{[2
]}

Butcher, Lee M. ^{[3
]}

Pollara, Gabriele ^{[1
]}

Kriston-Vizi, Janos ^{[4
]}

Venturini, Cristina ^{[1
]}

Austin, Rachel ^{[1
]}

de Castro, Karina Ferreira ^{[5
]}

Ketteler, Robin ^{[4
]}

Chain, Benjamin ^{[1
]}

Goldstein, Richard A. ^{[1
]}

Weiss, Robin A. ^{[1
]}

Beck, Stephan ^{[3
]}

Fassati, Ariberto ^{[1
]}

机构：

[1] UCL, Div Infect & Immun, Dept Infect, Cruciform Bldg,90 Gower St, London WC1E 6BT, England

[2] Univ Messina, Dept Vet Sci, Polo Univ Annunziata, I-98168 Messina, Italy

[3] UCL, Canc Inst, Dept Canc Biol, 72 Huntley St, London WC1E 6BT, England

[4] UCL, MRC Lab Mol Cell Biol, Gower St, London WC1E 6BT, England

[5] Univ Cambridge, Dept Vet Med, Transmissible Canc Grp, Madingley Rd, Cambridge CB3 0ES, England

来源：

CANCER CELL | 2018年 / 33卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

ADAPTIVE IMMUNE-RESPONSES; DNA METHYLATION; CELLS; PROLIFERATION; CHEMOKINES; EVOLUTION; MELANOMA; BIOLOGY; DEVIL; GENE;

D O I：

10.1016/j.ccell.2018.03.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The canine transmissible venereal tumor (CTVT) is a clonally transmissible cancer that regresses spontaneously or after treatment with vincristine, but we know little about the regression mechanisms. We performed global transcriptional, methylation, and functional pathway analyses on serial biopsies of vincristine-treated CTVTs and found that regression occurs in sequential steps; activation of the innate immune system and host epithelial tissue remodeling followed by immune infiltration of the tumor, arrest in the cell cycle, and repair of tissue damage. We identified CCL5 as a possible driver of CTVT regression. Changes in gene expression are associated with methylation changes at specific intragenic sites. Our results underscore the critical role of host innate immunity in triggering cancer regression.

引用

页码：620 / +

页数：20

共 74 条

[1]

Differential expression analysis for sequence count data [J].

Anders, Simon ;

Huber, Wolfgang .

GENOME BIOLOGY, 2010, 11 (10)

[2]

HTSeq-a Python']Python framework to work with high-throughput sequencing data [J].

Anders, Simon ;

Pyl, Paul Theodor ;

Huber, Wolfgang .

BIOINFORMATICS, 2015, 31 (02) :166-169

[3]

Contagious cancer: Lessons from the devil and the dog [J].

Belov, Katherine .

BIOESSAYS, 2012, 34 (04) :285-292

[4]

CPG-RICH ISLANDS AND THE FUNCTION OF DNA METHYLATION [J].

BIRD, AP .

NATURE, 1986, 321 (6067) :209-213

[5]

Blaine D. P., 1810, DOMESTIC TREATISE DI

[6]

Near-optimal probabilistic RNA-seq quantification [J].

Bray, Nicolas L. ;

Pimentel, Harold ;

Melsted, Pall ;

Pachter, Lior .

NATURE BIOTECHNOLOGY, 2016, 34 (05) :525-527

[7]

Gene-expression profiling to identify genes related to spontaneous tumor regression in a canine cancer model [J].

Chiang, Hsin-Chien ;

Liao, Albert Tai-Ching ;

Jan, Tong-Rong ;

Wang, Yu-Shan ;

Lei, Han-Jung ;

Tsai, Mong-Hsun ;

Chen, Mo-Fen ;

Lee, Chien-Yueh ;

Lin, Yi-Chen ;

Chu, Rea-Min ;

Lin, Chen-Si .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2013, 151 (3-4) :207-216

[8]

Chu RM, 2001, ANTICANCER RES, V21, P4017

[9]

THE CANINE TRANSMISSIBLE VENEREAL TUMOR - A UNIQUE RESULT OF TUMOR PROGRESSION [J].

COHEN, D .

ADVANCES IN CANCER RESEARCH, 1985, 43 :75-112

[10]

p63 in Epithelial Survival, Germ Cell Surveillance, and Neoplasia [J].

Crum, Christopher P. ;

McKeon, Frank. D. .

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2010, 5 :349-371

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