Isonicotinic acid hydrazide: an anti-tuberculosis drug inhibits malarial transmission in the mosquito gut

被引：18

作者：

Arai, M ^{[1
]}

Alavi, YIH

Mendoza, J

Billker, O

Sinden, RE

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Sci Biol, London SW7 2AZ, England

[2] Jichi Med Sch, Dept Med Zool, Tochigi 3290498, Japan

来源：

EXPERIMENTAL PARASITOLOGY | 2004年 / 106卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

Plasmodium berghei; Plasmodium gallinaceum; Anopheles stephensi; Aedes aegypti; transmission-blocking antimalarial; isonicotinic acid hydrazide; xanthurenic acid; gametocyte activating factor; hepes-buffered suspended animation medium; exflagellation index; ED50; half-maximal effective dose;

D O I：

10.1016/j.exppara.2004.01.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

We studied the transmission-blocking effect of isonicotinic acid hydrazide (INH), a widely used anti-tuberculosis drug, against Plasmodium gallinaceum and Plasmodium berghei. INH-treatment of infected animals did not inhibit parasite development in the blood of the vertebrate host, but did inhibit exflagellation, ookinete formation, and oocyst development in the mosquito. Oocyst development was inhibited in a dose-dependent manner. The ED50 in the P. gallinaceum/chicken/Aedes aegypti model and P. berghei/mouse/Anopheles stephensi model was 72 and 109mg/kg, respectively. In marked contrast, in vitro exflagellation and ookinete development were not directly affected by physiological concentrations of INK We suggest that INH exerts its inhibitory effects on the mosquito stages of the malaria parasite by an indirect, and at present undefined mechanism. Further elucidation of the mechanism how INH inhibits parasite development specifically on mosquito stages may allow us to identify new targets for malaria control strategy. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：30 / 36

页数：7

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