Identification and determination of metabolites and degradation products of sulfonamide antibiotics

被引：445

作者：

Jesus Garcia-Galan, M. ^{[1
]}

Silvia Diaz-Cruz, M. ^{[1
]}

Barcelo, Damia ^{[2
]}

机构：

[1] CSIC, Spanish Council Sci Res, Inst Environm Assessment & Water Res, Dept Environm Chem, E-08034 Barcelona, Spain

[2] Univ Girona, ICRA, Catalan Inst Water Res, E-17003 Girona, Spain

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2008年 / 27卷 / 11期

关键词：

Acetylation; Antibiotic; Degradation product; Elimination rate; Environmental analysis; Hydroxylation; Mass spectrometry; Metabolite; Sulfonamide; Toxicity;

D O I：

10.1016/j.trac.2008.10.001

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

Sulfonamide residues have been detected in all kinds of environmental water matrix. However, little attention has been so far paid to their metabolites and degradation products, and very few articles have included them in their analytical scope. The main goal of this article is to review those research studies in which both parent drugs and their respective metabolites have been considered together. We review the analytical methodologies used and assess biotic and abiotic degradation mechanisms of these antibiotics, and briefly evaluate their potential toxicity in the environment. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1008 / 1022

页数：15

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