Can unresolved infection precipitate autoimmune disease?

被引：18

作者：

Marks, D. J. B.

Mitchison, N. A.

Segal, A. W.

Sieper, J.

机构：

[1] UCL, Windeyer Inst Med Sci, Dept Immunol, London W1T 4JF, England

[2] UCL, Ctr Mol Med, London WC1E 6JJ, England

[3] Charite Univ Med Berlin, Dept Rheumatol, D-12200 Berlin, Germany

来源：

CURRENT CONCEPTS IN AUTOIMMUNITY AND CHRONIC INFLAMATION | 2006年 / 305卷

关键词：

D O I：

10.1007/3-540-29714-6_6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases are frequently postulated to arise as post-infectious phenomena. Here we survey the evidence supporting these theories, with particular emphasis on Crohn's disease and ankylosing spondylitis. Direct proof that infection establishes persistent autoimmunity remains lacking, although it may provoke a prolonged inflammatory response when occurring on a susceptible immunological background. The argument of infective causality is by no means trivial, since it carries important consequences for the safety of vaccine development.

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页码：105 / 125

页数：21

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