Evolution of the Cancer Stem Cell Model

被引：2043

作者：

Kreso, Antonija ^{[1
,2
]}

Dick, John E. ^{[1
,2
]}

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 1L7, Canada

[2] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada

来源：

CELL STEM CELL | 2014年 / 14卷 / 03期

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; B-16 MELANOMA VARIANTS; IMMUNE-DEFICIENT MICE; BREAST-CANCER; IN-VITRO; BONE-MARROW; PROSPECTIVE IDENTIFICATION; MUTATIONAL PROCESSES; TUMOR HETEROGENEITY;

D O I：

10.1016/j.stem.2014.02.006

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Genetic analyses have shaped much of our understanding of cancer. However, it is becoming increasingly clear that cancer cells display features of normal tissue organization, where cancer stem cells (CSCs) can drive tumor growth. Although often considered as mutually exclusive models to describe tumor heterogeneity, we propose that the genetic and CSC models of cancer can be harmonized by considering the role of genetic diversity and nongenetic influences in contributing to tumor heterogeneity. We offer an approach to integrating CSCs and cancer genetic data that will guide the field in interpreting past observations and designing future studies.

引用

页码：275 / 291

页数：17

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