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Deprive to kill Glutamine closes the gate to anticancer monocarboxylic drugs
被引：5
作者：
Cardaci, Simone
[1
]
Ciriolo, Maria Rosa
[1
,2
]
机构：
[1] Univ Roma Tor Vergata, Dept Biol, Rome, Italy
[2] IRCCS San Raffaele Pisana, Rome, Italy
来源：
关键词：
glutamine deprivation;
metabolic oxidative stress;
MCT-1;
chemopotentiation;
3-bromopyruvate;
D O I：
10.4161/auto.21795
中图分类号：
Q2 [细胞生物学];
学科分类号：
071013 [干细胞生物学];
摘要：
Killing properties of antitumor drugs can be enhanced by strategies targeting biochemical adaptations of cancer cells. Recently, we reported that depriving cancer cells of glutamine is a feasible approach to enhance antitumor effects of the alkylating analog of pyruvic acid, 3-bromopyruvate, which rely on the induction of autophagic cell death by metabolic-oxidative stress. 3-bromopyruvate chemopotentiation is the result of its increased intracellular uptake mediated by the monocarboxylate transporter 1, whose expression is post-transcriptionally increased upon glutamine withdrawal. Overall, our results identified the metabolic condition able to increase the selectivity of 3-bromopyruvate targets in neoplastic tissues, thereby providing a stage for its use in clinical settings for targeting malignancies and represent a proof of principle that modulation of glutamine availability can influence the delivery of monocarboxylic drugs into tumors.
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页码：1830 / 1832
页数：3
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