Toxicokinetics of fumonisin B1 in Turkey poults and tissue persistence after exposure to a diet containing the maximum European tolerance for fumonisins in avian feeds

The kinetic of fumonisin B1 (FB1) after a single IV and oral dose, and FB1 persistence in tissue were investigated in turkey poults by HPLC after purification of samples on columns. After IV administration (single-dose: 10mg FB1/kg bw), serum concentration-time curves were best described by a three-compartment open model, Elimination half-life and mean residence time of FBI were 85 and 52 min, respectively. After oral administration (single-dose: 100 mg FB1/kg bw) bioavailability was 3.2%; elimination half-life and mean residence time were 214 and 408 min, respectively. Clearance of FBI was 7.6 and 7.5 ml/min/kg for IV and oral administration, respectively. Twenty-four hours after the administration of FBI by the intravenous route, liver and kidney contained the highest levels of FBI in tissues, level in muscle was low or below the limit of detection (LD, 13 mu g/kg). The persistence of FBI in tissue was also studied after administration for 9 weeks of a feed that contained 5, 10 and 20 mg FB1 + FB2/kg diet. Eight hours after the last intake of 20 mg FB1+FB2/kg feed (maximum recommended concentration of fumonisins established by the EU for avian feed), hepatic and renal FBI concentrations were 119 and 22 mu g/kg, level in muscles was below the LD. (C) 2008 Elsevier Ltd. All rights reserved.