The role of melatonin treatment in chronic kidney disease

被引：42

作者：

Russcher, Marije ^{[1
]}

Koch, Birgit ^{[2
]}

Nagtegaal, Elsbeth ^{[1
]}

van der Putten, Karien ^{[3
]}

ter Wee, Piet ^{[4
]}

Gaillard, Carlo ^{[4
,5
]}

机构：

[1] Meander Med Ctr, Dept Hosp Pharm, NL-3800 BM Amersfoort, Netherlands

[2] Erasmus MC, Dept Hosp Pharm, Rotterdam, Netherlands

[3] Leiden Univ, Med Ctr, Dept Nephrol, Leiden, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, Dept Nephrol, Amsterdam, Netherlands

[5] Meander Med Ctr, Dept Internal Med, NL-3800 BM Amersfoort, Netherlands

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2012年 / 17卷

关键词：

Melatonin; Chronic Kidney Disease; Hemodialysis; Sleep Disturbances; 24-Hour Blood Pressure; Oxidative Stress; Review; COGNITIVE-BEHAVIORAL THERAPY; CIRCADIAN BLOOD-PRESSURE; CHRONIC-RENAL-FAILURE; TUMOR-NECROSIS-FACTOR; SLEEP PHASE SYNDROME; OXIDATIVE STRESS; CLINICAL-IMPLICATIONS; DAYTIME HEMODIALYSIS; EXOGENOUS MELATONIN; PERITONEAL-DIALYSIS;

D O I：

10.2741/4075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The pineal hormone melatonin plays a major role in circadian sleep-wake rhythm. Patients with Chronic Kidney Disease (CKD), especially those who are on hemodialysis, frequently suffer from sleep disturbances. In this review an overview is given of the classification of stages of chronic kidney disease, followed by a presentation of the circadian rhythm disorders in renal disease involving sleep disturbances in relation to melatonin deficiency. The therapeutic benefit of melatonin treatment in sleep disorders related to chronic kidney disease including the controlled trials solving this topic, is described. Furthermore, the beneficial effect of melatonin on blood pressure alterations in CKD states and the protection of melatonin in oxidative stress and inflammation in renal disorders are explored. Finally a hypothetic model is described for the relation between circadian rhythm disorders and CKD.

引用

页码：2644 / 2656

页数：13

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