DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

被引：498

作者：

Cheung-Ong, Kahlin ^{[1
,2
]}

Giaever, Guri ^{[3
]}

Nislow, Corey ^{[3
]}

机构：

[1] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada

[2] Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada

[3] Univ British Columbia, Dept Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada

来源：

CHEMISTRY & BIOLOGY | 2013年 / 20卷 / 05期

关键词：

GENOME-WIDE SCREEN; CENTRAL-NERVOUS-SYSTEM; SACCHAROMYCES-CEREVISIAE; ANTITUMOR-ACTIVITY; IN-VITRO; PLATINUM; CISPLATIN; DOXORUBICIN; GENES; YEAST;

D O I：

10.1016/j.chembiol.2013.04.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

DNA-damaging agents have a long history of use in cancer chemotherapy. The full extent of their cellular mechanisms, which is essential to balance efficacy and toxicity, is often unclear. In addition, the use of many anticancer drugs is limited by dose-limiting toxicities as well as the development of drug resistance. Novel anticancer compounds are continually being developed in the hopes of addressing these limitations; however, it is essential to be able to evaluate these compounds for their mechanisms of action. This review covers the current DNA-damaging agents used in the clinic, discusses their limitations, and describes the use of chemical genomics to uncover new information about the DNA damage response network and to evaluate novel DNA-damaging compounds.

引用

页码：648 / 659

页数：12

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