Neural Correlates of Caregiver Burden in Cortical Basal Syndrome and Frontotemporal Dementia

被引：28

作者：

Knutson, K. M. ^{[1
]}

Zamboni, G. ^{[1
,2
]}

Tierney, M. C. ^{[1
]}

Grafman, J. ^{[1
]}

机构：

[1] NINDS, Cognit Neurosci Sect, NIH, Bethesda, MD 20892 USA

[2] Univ Modena, Dipartimento Neurosci, I-41100 Modena, Italy

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2008年 / 26卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Corticobasal syndrome; Frontotemporal dementia; Magnetic resonance imaging; Voxel-based morphometry; Caregiver burden;

D O I：

10.1159/000167268

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

Aims: To determine areas of atrophy in patients that are associated with caregiver burden. Methods: We measured caregiver burden, dementia and neuropsychiatric scores in 22 patients with corticobasal syndrome (CBS) and 25 with frontotemporal dementia (FTD), and in 14 healthy controls. We used voxel-based morphometry to correlate caregiver burden with gray matter loss. Results: Increased dementia and behavioral disturbances contributed to higher burden scores in CBS patients, while behavioral disturbances alone significantly affected burden scores in frontal-variant FTD (FTD-fv) patients. In CBS patients, caregiver burden scores correlated with atrophy in left inferior and middle temporal gyri. Conclusions: Caregivers of FTD-fv patients had significantly higher burden scores than caregivers of CBS patients. Damage to areas important in semantic knowledge appears critical in increased burden for CBS caregivers. Copyright (C) 2008 S. Karger AG, Basel

引用

页码：467 / 474

页数：8

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