Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana

被引：36

作者：

Du, XM

Sun, NY

Takizawa, N

Guo, YT

Shoyama, Y

机构：

[1] Kyushu Univ, Grad Sch Pharmaceut Sci, Higahi Ku, Fukuoka 8128582, Japan

[2] Seiwa Pharmaceut Ltd, Minato Ku, Tokyo 1058585, Japan

[3] Dalian Inst Med & Pharmaceut Sci, Dalian 116013, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2002年 / 16卷 / 03期

关键词：

goodyerin; flavonoids; CNS activity; Anoectochilus formosanus; Goodyera schlechtendaliana;

D O I：

10.1002/ptr.862

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Goodyerin is a flavonol glycoside isolated from the whole plants of Goodyera schlechtendaliana which has been used as a substitute for the crude drug, Anoectochilus formosanus. The pharmacological propel-ties of goodyerin were assayed for effects oil spontaneous locomotor activity, on pentobarbital-induced hypnosis, and on anticonvulsant activity against picrotoxin-induced seizures in rodents. Goodyerin exhibited a significant and close-dependent sedative and anticonvulsant effect. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：261 / 263

页数：3

共 18 条

[1]

DANDIYA PC, 1959, J PHARMACOL EXP THER, V125, P353

[2]

DELGADOESCUETA AV, 1986, ADV NEUROL, V4, P3

[3]

Flavonoids from Goodyera schlechtendaliana [J].