The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in Development, Disease, and Therapy

被引：140

作者：

Lehtinen, Maria K. ^{[1
]}

Bjornsson, Christopher S. ^{[2
]}

Dymecki, Susan M. ^{[3
]}

Gilbertson, Richard J. ^{[4
]}

Holtzman, David M. ^{[5
]}

Monuki, Edwin S. ^{[6
]}

机构：

[1] Harvard Univ, Sch Med, Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA

[2] Neural Stem Cell Inst, Rensselaer, NY 12144 USA

[3] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[4] St Jude Childrens Res Hosp, Memphis, TN 38105 USA

[5] Washington Univ, Dept Neurobiol, St Louis, MO 63110 USA

[6] Univ Calif Irvine, Sch Med, Dept Pathol & Lab Med, Irvine, CA 92697 USA

来源：

JOURNAL OF NEUROSCIENCE | 2013年 / 33卷 / 45期

基金：

美国国家卫生研究院;

关键词：

CENTRAL-NERVOUS-SYSTEM; CELL-CYCLE PROGRESSION; NEURAL STEM-CELLS; SONIC HEDGEHOG; ROOF PLATE; ALZHEIMERS-DISEASE; RHOMBIC LIP; BRAIN; NEUROGENESIS; NICHE;

D O I：

10.1523/JNEUROSCI.3258-13.2013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although universally recognized as the source of cerebrospinal fluid (CSF), the choroid plexus (ChP) has been one of the most understudied tissues in neuroscience. The reasons for this are multiple and varied, including historical perceptions about passive and permissive roles for the ChP, experimental issues, and lack of clinical salience. However, recent work on the ChP and instructive signals in the CSF have sparked new hypotheses about how the ChP and CSF provide unexpected means for regulating nervous system structure and function in health and disease, as well as new ChP-based therapeutic approaches using pluripotent stem cell technology. This minisymposium combines new and established investigators to capture some of the newfound excitement surrounding the ChP-CSF system.

引用

页码：17553 / 17559

页数：7

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