Flavonoids from the Heartwood of Dalbergia odorifera and Their Protective Effect on Glutamate-Induced Oxidative Injury in HT22 Cells

被引：64

作者：

An, Ren-Bo ^{[1
,3
]}

Jeong, Gil-Saeng ^{[2
]}

Kim, Youn-Chul ^{[1
]}

机构：

[1] Wonkwang Univ, Coll Pharm, Iksan 570749, South Korea

[2] Wonkwang Univ, Inst Radiol Imaging Sci, Iksan 570749, South Korea

[3] Yanbian Univ, Coll Pharm, Yanji 133000, Jilin, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 12期

关键词：

Dalbergia odorifera; Leguminosae; flavonoid; arylbenzofuran;

D O I：

10.1248/cpb.56.1722

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Two flavonoids, 4,2',5'-trihydroxy-4'-methoxychalcone (1) and (2S)-6,7,4'-trihydroxyflavan (2), along with fourteen known flavonoids and two other known arylbenzofurans were isolated from the heartwood of Dalbergia odorifera. The structure of compounds 1 and 2 were established by spectroscopic (NMR and MS) analyses. Of the isolates, eight compounds (1, 4, 7, 10, 12, 14, 15, 17) were found to have potent protective effect on glutamate-induced oxidative injury in HT22 cells.

引用

页码：1722 / 1724

页数：3

共 22 条

[1]

CONSTITUENTS OF TROPICAL MEDICINAL PLANTS .31. FLAVONOID AND OTHER CONSTITUENTS OF BAUHINIA-MANCA [J].

ACHENBACH, H ;

STOCKER, M ;

CONSTENLA, MA .

PHYTOCHEMISTRY, 1988, 27 (06) :1835-1841

[2]

AGRAWAL PK, 1989, CARBON 13 NMR FLAVON, P365

[3]

CARDILLO B, 1970, TETRAHEDRON LETT, P4367

[4]

Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera [J].

Chan, SC ;

Chang, YS ;

Wang, JP ;

Chen, SC ;

Kuo, SC .

PLANTA MEDICA, 1998, 64 (02) :153-158

[5]

Neoflavonoids from Dalbergia odorifera [J].

Chan, SC ;

Chang, YS ;

Kuo, SC .

PHYTOCHEMISTRY, 1997, 46 (05) :947-949

[6]

DALBERGIA SPECIES .12. NEOFLAVANOIDS OF DALBERGIA-MELANOXYLON [J].

DONNELLY, DMX ;

OREILLY, J ;

WHALLEY, WB .

PHYTOCHEMISTRY, 1975, 14 (10) :2287-2290

[7]

NEOFLAVANOID GROUP OF NATURAL PRODUCTS .I. DALBERGIONES - A NEW CLASS OF QUINONES [J].

EYTON, WB ;

OLLIS, WD ;

SUTHERLAND, IO ;

GOTTLIEB, OR ;

MAGALHAES, MT ;

JACKMAN, IM .

TETRAHEDRON, 1965, 21 (09) :2683-+

[8]

GODA Y, 1992, CHEM PHARM BULL, V40, P2452, DOI 10.1248/cpb.40.2452

[9]

NEOFLAVONOID GROUP OF NATURAL-PRODUCTS .8. OBTUSASTYRENE AND OBTUSTYRENE, CINNAMYLPHENOLS FROM DALBERGIA-RETUSA [J].

GREGSON, M ;

OLLIS, WD ;

REDMAN, BT ;

SUTHERLAND, IO ;

DIETRICHS, HH ;

GOTTLIEB, OR .

PHYTOCHEMISTRY, 1978, 17 (08) :1395-1400

[10]

Kang Tai Hyun, 2005, Journal of Applied Pharmacology, V13, P32

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