Steric versus electronic effects of the ligand in the enantioselective palladium-catalyzed allylic alkylation with chiral oxazolinylpyridines

被引：36

作者：

Chelucci, G

Deriu, S

Pinna, GA

Saba, A

Valenti, R

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

[2] Univ Sassari, Dipartimento Farmaco Chim Tossicol, I-07100 Sassari, Italy

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 19期

关键词：

D O I：

10.1016/S0957-4166(99)00368-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral oxazolinylpyridines bearing an oxazolinyl [bis(oxazolinyl)pyridines] or a cyano group in the 6-position of the pyridine ring were prepared and assessed in the enantioselective palladium-catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. The electronic and steric properties of substituents hardly affected either the catalytic activity or the enantioselectivity of the substitution reaction. Enantioselectivities up to 94% were obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：3803 / 3809

页数：7

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