Highly efficient and diastereoselective synthesis of (+)-lineatin

被引：31

作者：

Alibés, R

de March, P

Figueredo, M

Font, J

Racamonde, M

Parella, T

机构：

[1] Univ Autonoma Barcelona, Dept Quim, Bellaterra 08193, Spain

[2] Univ Autonoma Barcelona, Servei Ressonancia Magnet Nucl, Bellaterra 08193, Spain

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 09期

关键词：

D O I：

10.1021/ol0497032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A linear sequence was used to synthesize (+)-lineatin in 14 steps and 14% overall yield from a homochiral 2(5H)-furanone. Key steps of this synthetic approach feature the diastereoselective construction of a cyclobutene through a photochemical [2 + 2] cycloaddition and a regiocontrolled oxymercuration reaction.

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页码：1449 / 1452

页数：4

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