A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains

被引：19

作者：

Kimura, N

Ueno, M

Nakashima, K

Taga, T ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Inst Med Res, Dept Mol Cell Biol, Tokyo 1010062, Japan

[2] Chugai Res Inst Mol Med, Gene Search Program, Ibaraki, Osaka, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 1999年 / 126卷 / 01期

关键词：

developing CNS; Ldb1; Lhx6.1; LIM-homeodomain (LHX) gene; protein-protein interaction;

D O I：

10.1093/oxfordjournals.jbchem.a022420

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LIM-homeodomain (LHX) transcription factors play critical roles in cell fate determination during development, in particular, in CNS, The transcriptional activity of several LHX proteins is postulated to be regulated by interaction with an LIM-domain binding protein, Ldb1, We have now identified a novel LHX molecule, termed Lhx6.1, that is closely related to a recently reported Lhx6 molecule. The Lhx6.1 transcript is found in several restricted regions in the developing CNS, mostly within the embryonic forebrain, We further show that Lhx6.1 interacts with Ldb1 through tandem LIM-domains, implying transcriptional regulation of Lhx6.1 by Ldb1.

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收藏

页码：180 / 187

页数：8

相关论文

共 25 条

[1] Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins [J].

Agulnick, AD ;

Taira, M ;

Breen, JJ ;

Tanaka, T ;

Dawid, IB ;

Westphal, H .

NATURE, 1996, 384 (6606) :270-272

[2] A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins [J].

Bach, I ;

Carriere, C ;

Ostendorff, HP ;

Andersen, B ;

Rosenfeld, MG .

GENES & DEVELOPMENT, 1997, 11 (11) :1370-1380

[3] THE RHOMBOTIN FAMILY OF CYSTEINE-RICH LIM-DOMAIN ONCOGENES - DISTINCT MEMBERS ARE INVOLVED IN T-CELL TRANSLOCATIONS TO HUMAN CHROMOSOME-11P15 AND CHROMOSOME-11P13 [J].

BOEHM, T ;

FORONI, L ;

KANEKO, Y ;

PERUTZ, MF ;

RABBITTS, TH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4367-4371

[4] Interactions between LIM domains and the LIM domain-binding protein Ldb1 [J].

Breen, JJ ;

Agulnick, AD ;

Westphal, S ;

Dawid, IB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (08) :4712-4717

[5]

DAWID IB, 1995, CR ACAD SCI III-VIE, V318, P295

[6] LIM domains: multiple roles as adapters and functional modifiers in protein interactions [J].

Dawid, IB ;

Breen, JJ ;

Toyama, R .

TRENDS IN GENETICS, 1998, 14 (04) :156-162

[7] THE RHOMBOTIN GENE FAMILY ENCODE RELATED LIM-DOMAIN PROTEINS WHOSE DIFFERING EXPRESSION SUGGESTS MULTIPLE ROLES IN MOUSE DEVELOPMENT [J].

FORONI, L ;

BOEHM, T ;

WHITE, L ;

FORSTER, A ;

SHERRINGTON, P ;

LIAO, XB ;

BRANNAN, CI ;

JENKINS, NA ;

COPELAND, NG ;

RABBITTS, TH .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 226 (03) :747-761

[8] SEGMENTAL AND DEVELOPMENTAL REGULATION OF A PRESUMPTIVE T-CELL ONCOGENE IN THE CENTRAL-NERVOUS-SYSTEM [J].

GREENBERG, JM ;

BOEHM, T ;

SOFRONIEW, MV ;

KEYNES, RJ ;

BARTON, SC ;

NORRIS, ML ;

SURANI, MA ;

SPILLANTINI, MG ;

RABBITTS, TH .

NATURE, 1990, 344 (6262) :158-160

[9]

Grigoriou M, 1998, DEVELOPMENT, V125, P2063

[10] Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: The LIM2 domain determines specificity [J].

Johnson, JD ;

Zhang, WG ;

Rudnick, A ;

Rutter, WJ ;

German, MS .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (07) :3488-3496