Transcription factor target practice

被引：19

作者：

Holstege, FCP

Clevers, H

机构：

[1] Univ Utrecht, Med Ctr, Dept Physiol Chem, NL-3584 CG Utrecht, Netherlands

[2] Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

[3] Ctr Biomed Genet, NL-3584 CT Utrecht, Netherlands

来源：

CELL | 2006年 / 124卷 / 01期

关键词：

D O I：

10.1016/j.cell.2005.12.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In this issue of Cell, Hallikas et al. (2006) and Wei et al. (2006) describe different ways of identifying direct targets of transcription factors and their corresponding regulatory sequences in the genome. Although still under development, these studies provide an efficient way to decipher regulatory networks.

引用

收藏

页码：21 / 23

页数：3

相关论文

共 9 条

[1]

Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs [J].

Cawley, S ;

Bekiranov, S ;

Ng, HH ;

Kapranov, P ;

Sekinger, EA ;

Kampa, D ;

Piccolboni, A ;

Sementchenko, V ;

Cheng, J ;

Williams, AJ ;

Wheeler, R ;

Wong, B ;

Drenkow, J ;

Yamanaka, M ;

Patel, S ;

Brubaker, S ;

Tammana, H ;

Helt, G ;

Struhl, K ;

Gingeras, TR .

CELL, 2004, 116 (04) :499-509

[2]

Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity [J].

Hallikas, O ;

Palin, K ;

Sinjushina, N ;

Rautiainen, R ;

Partanen, J ;

Ukkonen, E ;

Taipale, J .

CELL, 2006, 124 (01) :47-59

[3]

Micrornas: Small RNAs with a big role in gene regulation [J].

He, L ;

Hannon, GJ .

NATURE REVIEWS GENETICS, 2004, 5 (07) :522-531

[4]

Common themes in the function of transcription and splicing enhancers [J].

Hertel, KJ ;

Lynch, KW ;

Maniatis, T .

CURRENT OPINION IN CELL BIOLOGY, 1997, 9 (03) :350-357

[5]

Analysis of chromatin structure by in vivo formaldehyde cross-linking [J].

Orlando, V ;

Strutt, H ;

Paro, R .

METHODS-A COMPANION TO METHODS IN ENZYMOLOGY, 1997, 11 (02) :205-214

[6]

TRANSCRIPTION FACTORS - STRUCTURAL FAMILIES AND PRINCIPLES OF DNA RECOGNITION [J].

PABO, CO ;

SAUER, RT .

ANNUAL REVIEW OF BIOCHEMISTRY, 1992, 61 :1053-1095

[7]

Genome-wide location and function of DNA binding proteins [J].

Ren, B ;

Robert, F ;

Wyrick, JJ ;

Aparicio, O ;

Jennings, EG ;

Simon, I ;

Zeitlinger, J ;

Schreiber, J ;

Hannett, N ;

Kanin, E ;

Volkert, TL ;

Wilson, CJ ;

Bell, SP ;

Young, RA .

SCIENCE, 2000, 290 (5500) :2306-+

[8]

WEI CL, 2006, CELL

[9]

Biomedical discovery with DNA arrays [J].

Young, RA .

CELL, 2000, 102 (01) :9-15