Recombinant bovine somatotropin decreases hepatic amino acid catabolism in female rats

被引:10
作者
Blemings, KP
Gahl, MJ
Crenshaw, TD
Benevenga, NJ
机构
[1] UNIV WISCONSIN, DEPT NUTR SCI, MADISON, WI 53706 USA
[2] UNIV WISCONSIN, DEPT MEAT & ANIM SCI, MADISON, WI 53706 USA
关键词
rats; somatotropin; lysine; methionine; valine;
D O I
10.1093/jn/126.6.1657
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The effect of recombinant bovine somatotropin (rbST) on hepatic amino acid catabolism in female rats was investigated. Daily injections of rbST for 5 d decreased liver homogenate lysine alpha-ketoglutarate reductase (EC 1.5.1.8) activity (P < 0.05) and liver homogenate lysine oxidation (P < 0.05) similar to 35%. Liver homogenate methionine and valine oxidation were depressed similar to 20 (P = 0.13) and 35% (P < 0.05), respectively. These data show a decrease in hepatic capacity to oxidize amino acids in rats administered rbST. Whether depressed liver amino acid degrading enzyme activity plays a role in amino acid oxidation in vivo remains to be evaluated.
引用
收藏
页码:1657 / 1661
页数:5
相关论文
共 38 条
[1]   ANALYSIS OF EARLY RESPONSES TO GROWTH-HORMONE ON AMINO-ACID-TRANSPORT AND PROTEIN-SYNTHESIS IN DIAPHRAGMS OF YOUNG NORMAL RATS [J].
ALBERTSSONWIKLAND, K ;
EDEN, S ;
ISAKSSON, O .
ENDOCRINOLOGY, 1980, 106 (01) :291-297
[2]   IDENTIFICATION OF JAK2 AS A GROWTH-HORMONE RECEPTOR-ASSOCIATED TYROSINE KINASE [J].
ARGETSINGER, LS ;
CAMPBELL, GS ;
YANG, XN ;
WITTHUHN, BA ;
SILVENNOINEN, O ;
IHLE, JN ;
CARTERSU, C .
CELL, 1993, 74 (02) :237-244
[3]   COMPARISON OF THE GROWTH-PROMOTING PROPERTIES OF DAILY VERSUS CONTINUOUS ADMINISTRATION OF SOMATOTROPIN IN FEMALE RATS WITH INTACT PITUITARIES [J].
AZAIN, MJ ;
KASSER, TR ;
SABACKY, MJ ;
BAILE, CA .
JOURNAL OF ANIMAL SCIENCE, 1993, 71 (02) :384-392
[4]  
BEATON GH, 1953, P SOC EXP BIOL MED, V83, P781
[5]   SOME METABOLIC CHANGES INDUCED BY PRIMATE GROWTH HORMONE + PURIFIED OVINE PROLACTIN [J].
BECK, JC ;
HAMID, MA ;
RUBINSTEIN, D ;
GONDA, A ;
MORGEN, RO ;
MCGARRY, EE .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1964, 13 (10P) :1108-&
[6]  
Bell AW, 1987, J ANIMAL SCI S2, V65, P186, DOI [DOI 10.1093/ANSCI/65.SUPPL_, 10.1093/ansci/65.suppl_2.186, DOI 10.1093/ANSCI/65.SUPPL_2.186]
[7]   ROLE OF PROTEIN-SYNTHESIS IN AMINO-ACID CATABOLISM [J].
BENEVENGA, NJ ;
GAHL, MJ ;
BLEMINGS, KP .
JOURNAL OF NUTRITION, 1993, 123 (02) :332-336
[8]   LYSINE-ALPHA-KETOGLUTARATE REDUCTASE AND SACCHAROPINE DEHYDROGENASE ARE LOCATED ONLY IN THE MITOCHONDRIAL MATRIX IN RAT-LIVER [J].
BLEMINGS, KP ;
CRENSHAW, TD ;
SWICK, RW ;
BENEVENGA, NJ .
JOURNAL OF NUTRITION, 1994, 124 (08) :1215-1221
[9]  
BLEMINGS KP, 1994, THESIS U WISCONSIN M
[10]   NUTRIENT UTILIZATION AND PROTEIN-TURNOVER IN THE HINDLIMB OF CATTLE TREATED WITH BOVINE SOMATOTROPIN [J].
BOISCLAIR, YR ;
BAUMAN, DE ;
BELL, AW ;
DUNSHEA, FR ;
HARKINS, M .
JOURNAL OF NUTRITION, 1994, 124 (05) :664-673