How well do we understand the neural origins of the fMRI BOLD signal?

被引：284

作者：

Arthurs, OJ ^{[1
]}

Boniface, S ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Wolfson Brain Imaging Ctr, Cambridge CB2 2QQ, England

来源：

TRENDS IN NEUROSCIENCES | 2002年 / 25卷 / 01期

关键词：

D O I：

10.1016/S0166-2236(00)01995-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The successful use of functional magnetic resonance imaging (fMRI) as a way of visualizing cortical function depends largely on the important relationships between the signal observed and the underlying neuronal activity that it is believed to represent. Currently, a relatively direct correlation seems to be favoured between fMRI signals and population synaptic activity (including inhibitory and excitatory activity), with a secondary and potentially more variable correlation with cellular action potentials.

引用

页码：27 / 31

页数：5

共 63 条

[1]

ACKERMANN RF, 1984, J NEUROSCI, V4, P251

[2]

Cerebral blood flow increases evoked by electrical stimulation of rat cerebellar cortex: Relation to excitatory synaptic activity and nitric oxide synthesis [J].

Akgoren, N ;

Dalgaard, P ;

Lauritzen, M .

BRAIN RESEARCH, 1996, 710 (1-2) :204-214

[3]

POTENTIALS-EVOKED IN HUMAN AND MONKEY CEREBRAL-CORTEX BY STIMULATION OF THE MEDIAN NERVE - A REVIEW OF SCALP AND INTRACRANIAL RECORDINGS [J].

ALLISON, T ;

MCCARTHY, G ;

WOOD, CC ;

JONES, SJ .

BRAIN, 1991, 114 :2465-2503

[4]

Coupling of neural activation to blood flow in the somatosensory cortex of rats is time-intensity separable, but not linear [J].

Ances, BM ;

Zarahn, E ;

Greenberg, JH ;

Detre, JA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2000, 20 (06) :921-930

[5]

Linear coupling between functional magnetic resonance imaging and evoked potential amplitude in human somatosensory cortex [J].

Arthurs, OJ ;

Williams, EJ ;

Carpenter, TA ;

Pickard, JD ;

Boniface, SJ .

NEUROSCIENCE, 2000, 101 (04) :803-806

[6]

A LAMINAR ANALYSIS OF THE NUMBER OF ROUND-ASYMMETRICAL AND FLAT-SYMMETRICAL SYNAPSES ON SPINES, DENDRITIC TRUNKS, AND CELL-BODIES IN AREA 17 OF THE CAT [J].

BEAULIEU, C ;

COLONNIER, M .

JOURNAL OF COMPARATIVE NEUROLOGY, 1985, 231 (02) :180-189

[7]

THE INTRAVASCULAR CONTRIBUTION TO FMRI SIGNAL CHANGE - MONTE-CARLO MODELING AND DIFFUSION-WEIGHTED STUDIES IN-VIVO [J].

BOXERMAN, JL ;

BANDETTINI, PA ;

KWONG, KK ;

BAKER, JR ;

DAVIS, TL ;

ROSEN, BR ;

WEISSKOFF, RM .

MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (01) :4-10

[8]

Brinker G, 1999, MAGNET RESON MED, V41, P469, DOI 10.1002/(SICI)1522-2594(199903)41:3<469::AID-MRM7>3.0.CO

[9]

2-9

[10]

Dynamics of blood flow and oxygenation changes during brain activation: The balloon model [J].

Buxton, RB ;

Wong, EC ;

Frank, LR .

MAGNETIC RESONANCE IN MEDICINE, 1998, 39 (06) :855-864

← 1 2 3 4 5 6 7 →