Orchestrated leak provokes a thymus reassessment

被引：5

作者：

Hayday, A ^{[1
]}

机构：

[1] Kings Coll London, Sch Med, Dept Immunobiol, London SE1 9RT, England

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/ni0106-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The thymus is considered the source of mature lymphocytes and is not thought to produce progenitors with the capacity to develop into unconventional T cells in the periphery. That view requires revision.

引用

页码：9 / 11

页数：4

共 12 条

[1] Extrathymic TCR gene rearrangement in human small intestine:: Identification of new splice forms of recombination activating gene-1 mRNA with selective tissue expression [J].

Bas, A ;

Hammarström, SG ;

Hammarström, MLKC .

JOURNAL OF IMMUNOLOGY, 2003, 171 (07) :3359-3371

[2] Thymic origin of intestinal αβ T cells revealed by fate mapping of RORγt+ cells [J].

Eberl, G ;

Littman, DR .

SCIENCE, 2004, 305 (5681) :248-251

[3] Extrathymic T cell lymphopoiesis: Ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice [J].

Guy-Grand, D ;

Azogui, O ;

Celli, S ;

Darche, S ;

Nussenzweig, MC ;

Kourilsky, P ;

Vassalli, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (03) :333-341

[4] T/B lineage choice occurs prior to intrathymic Notch signaling [J].

Harman, BC ;

Jenkinson, WE ;

Parnell, SM ;

Rossi, SW ;

Jenkinson, EJ ;

Anderson, G .

BLOOD, 2005, 106 (03) :886-892

[5] Intraepithelial lymphocytes: exploring the Third Way in immunology [J].

Hayday, A ;

Theodoridis, E ;

Ramsburg, E ;

Shires, J .

NATURE IMMUNOLOGY, 2001, 2 (11) :997-1003

[6] Enterocyte expression of interleukin 7 induces development of γδ T cells and Peyer's patches [J].

Laky, K ;

Lefrançois, L ;

Lingenheld, EG ;

Ishikawa, H ;

Lewis, JM ;

Olson, S ;

Suzuki, K ;

Tigelaar, RE ;

Puddington, L .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (09) :1569-1580

[7] The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs [J].

Lambolez, F ;

Arcangeli, ML ;

Joret, AM ;

Pasqualetto, V ;

Cordier, C ;

Di Santo, JP ;

Rocha, B ;

Ezine, S .

NATURE IMMUNOLOGY, 2006, 7 (01) :76-82

[8] Precursors of functional MHC class I- or class II-restricted CD8αα+ T cells are positively selected in the thymus by agonist self-peptides [J].

Leishman, AJ ;

Gapin, L ;

Capone, M ;

Palmer, E ;

MacDonald, HR ;

Kronenberg, M ;

Cheroutre, H .

IMMUNITY, 2002, 16 (03) :355-364

[9] Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria [J].

Macpherson, AJ ;

Geuking, MB ;

McCoy, KD .

IMMUNOLOGY, 2005, 115 (02) :153-162

[10] A unique subset of self-specific intraintestinal T cells maintains gut integrity [J].

Poussier, P ;

Ning, T ;

Banerjee, D ;

Julius, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (11) :1491-1497

← 1 2 →