Novel asymmetric synthesis of a bicyclo[3.1.0]hexane derivative by an efficient retro-Diels-Alder strategy.

被引：15

作者：

Moher, ED

机构：

[1] Lilly Research Laboratories, Division of Eli Lilly and Company, Chem. Proc. R. and D. Division, Indianapolis

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(96)02025-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first preparation of enantiomerically pure bicyclo[3.1.0]hexane-2-one-6-carboxylic acid ethyl ester (1), a valuable synthetic intermediate, is described. The synthesis features a retro-Diels-Alder reaction as a key step. Conditions which allow for a high yielding thermal conversion of 3 to 4 are described. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8637 / 8640

页数：4

共 19 条

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