Within-day and between-day repeatability of measurements with an electronic nose in patients with COPD

被引：63

作者：

Bofan, Maria ^{[1
]}

Mores, Nadia ^{[2
]}

Baron, Marco ^{[1
]}

Dabrowska, Malgorzata ^{[2
]}

Valente, Salvatore ^{[3
]}

Schmid, Maurizio ^{[1
]}

Trove, Andrea ^{[4
]}

Conforto, Silvia ^{[1
]}

Zini, Gina ^{[5
]}

Cattani, Paola ^{[6
]}

Fuso, Leonello ^{[3
]}

Mautone, Antonella ^{[3
]}

Mondino, Chiara ^{[7
]}

Pagliari, Gabriella ^{[3
]}

D'Alessio, Tommaso ^{[1
]}

Montuschi, Paolo ^{[3
]}

机构：

[1] Univ Roma 3, Fac Engn, Dept Appl Elect, Rome, Italy

[2] Univ Cattolica Sacro Cuore, Fac Med, Dept Pharmacol, I-00168 Rome, Italy

[3] Univ Cattolica Sacro Cuore, Fac Med, Dept Internal Med & Geriatr, I-00168 Rome, Italy

[4] IDI, San Carlo di Nancy Hosp, Dept Med, Rome, Italy

[5] Univ Cattolica Sacro Cuore, Fac Med, Dept Hematol, I-00168 Rome, Italy

[6] Univ Cattolica Sacro Cuore, Fac Med, Dept Microbiol, I-00168 Rome, Italy

[7] IDI, Dept Immunodermatol, Rome, Italy

来源：

JOURNAL OF BREATH RESEARCH | 2013年 / 7卷 / 01期

关键词：

EXHALED NITRIC-OXIDE; VOLATILE ORGANIC-COMPOUNDS; LUNG-CANCER; BREATH CONDENSATE; DIAGNOSIS; DISCRIMINATION; ARRAY; FOOD;

D O I：

10.1088/1752-7155/7/1/017103

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Electronic noses (e-noses), artificial sensor systems generally consisting of chemical sensor arrays for the detection of volatile compound profiles, have potential applications in respiratory medicine. We assessed within-day and between-day repeatability of an e-nose made from 32 sensors in patients with stable chronic obstructive pulmonary disease (COPD). We also compared between-day repeatability of an e-nose, fraction of exhaled nitric oxide (FENO) and pulmonary function testing. Within-day and between-day repeatability for the e-nose was assessed in two breath samples collected 30 min and seven days apart, respectively. Repeatability was expressed as an intraclass correlation coefficient (ICC). All sensors had ICC above 0.5, a value that is considered acceptable for repeatability. Regarding within-day repeatability, ICC ranged from 0.75 to 0.84 (mean = 0.80 +/- 0.004). Sensors 6 and 19 were the most reproducible sensors (both, ICC = 0.84). Regarding between-day repeatability, ICC ranged from 0.57 to 0.76 (mean = 0.68 +/- 0.01). Sensor 19 was the most reproducible sensor (ICC = 0.76). Within-day e-nose repeatability was greater than between-day repeatability (P < 0.0001). Between-day repeatability of FENO (ICC = 0.91) and spirometry (ICC range = 0.94-0.98) was greater than that of e-nose (mean ICC = 0.68). In patients with stable COPD, the e-nose used in this study has acceptable within-day and between-day repeatability which varies between different sensors.

引用

页数：8

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