Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells

被引：51

作者：

Tao, Xinrong ^{[1
]}

Hill, Terence E. ^{[1
]}

Morimoto, Chikao ^{[4
]}

Peters, Clarence J. ^{[1
,3
]}

Ksiazek, Thomas G. ^{[2
]}

Tseng, Chien-Te K. ^{[1
,3
]}

机构：

[1] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[2] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA

[3] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA

[4] Juntendo Univ, Dept Therapy Dev & Innovat Immune Dis & Canc, Tokyo, Japan

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 17期

关键词：

INFECTION; EXPRESSION; RECEPTOR; CD26;

D O I：

10.1128/JVI.01562-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.

引用

页码：9953 / 9958

页数：6

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