The sterol-sensing domain: multiple families, a unique role?

被引：219

作者：

Kuwabara, PE ^{[1
]}

Labouesse, M

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[2] ULP, CNRS, INSERM, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/S0168-9525(02)02640-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The'sterol-sensing domain'(SSD) is conserved across phyla and is present in several membrane proteins, such as Patched (a Hedgehog receptor) and NPC-1 (the protein defective in Niemann-Pick type C1 disease). The role of the SSD is perhaps best understood from the standpoint of its involvement in cholesterol homeostasis. This article discusses how the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis.

引用

页码：193 / 201

页数：9

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