Epigenetic regulation of ageing: linking environmental inputs to genomic stability

被引：452

作者：

Benayoun, Berenice A. ^{[1
,2
]}

Pollina, Elizabeth A. ^{[1
,3
]}

Brunet, Anne ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[2] Stanford Univ, Paul F Glenn Labs Biol Aging, Stanford, CA 94305 USA

[3] Stanford Univ, Canc Biol Program, Stanford, CA 94305 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2015年 / 16卷 / 10期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

ELEGANS LIFE-SPAN; DNA METHYLATION CHANGES; NEURAL STEM-CELLS; GENE-EXPRESSION; CAENORHABDITIS-ELEGANS; TRANSPOSABLE ELEMENTS; C; ELEGANS; HISTONE METHYLATION; CALORIC RESTRICTION; CIRCADIAN-RHYTHMS;

D O I：

10.1038/nrm4048

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-based epigenetic changes that occur during ageing, the role of chromatin modifiers in modulating lifespan and the importance of epigenetic signatures as biomarkers of ageing. We also discuss how epigenome remodelling by environmental stimuli affects several aspects of transcription and genomic stability, with important consequences for longevity, and outline epigenetic differences between the 'mortal soma' and the 'immortal germ line'. Finally, we discuss the inheritance of characteristics of ageing and potential chromatin-based strategies to delay or reverse hallmarks of ageing or age-related diseases.

引用

页码：593 / 610

页数：18

共 194 条

[1]

Snf1/AMPK regulates Gcn5 occupancy, H3 acetylation and chromatin remodelling at S-cerevisiae ADY2 promoter [J].

Abate, Georgia ;

Bastonini, Emanuela ;

Braun, Katherine A. ;

Verdone, Loredana ;

Young, Elton T. ;

Caserta, Micaela .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2012, 1819 (05) :419-427

[2]

The circadian epigenome: how metabolism talks to chromatin remodeling [J].

Aguilar-Arnal, Lorena ;

Sassone-Corsi, Paolo .

CURRENT OPINION IN CELL BIOLOGY, 2013, 25 (02) :170-176

[3]

H3K4 demethylase activities repress proliferative and postmitotic aging [J].

Alvares, Stacy M. ;

Mayberry, Gaea A. ;

Joyner, Ebony Y. ;

Lakowski, Bernard ;

Ahmed, Shawn .

AGING CELL, 2014, 13 (02) :245-253

[4]

SIRT1 regulates circadian clock gene expression through PER2 deacetylation [J].

Asher, Gad ;

Gatfield, David ;

Stratmann, Markus ;

Reinke, Hans ;

Dibner, Charna ;

Kreppel, Florian ;

Mostoslavsky, Raul ;

Alt, Frederick W. ;

Schibler, Ueli .

CELL, 2008, 134 (02) :317-328

[5]

Increased cell-to-cell variation in gene expression in ageing mouse heart [J].

Bahar, Rumana ;

Hartmann, Claudia H. ;

Rodriguez, Karl A. ;

Denny, Ashley D. ;

Busuttil, Rita A. ;

Dolle, Martijn E. T. ;

Calder, R. Brent ;

Chisholm, Gary B. ;

Pollock, Brad H. ;

Klein, Christoph A. ;

Vijg, Jan .

NATURE, 2006, 441 (7096) :1011-1014

[6]

Regulating the Chromatin Landscape: Structural and Mechanistic Perspectives [J].

Bartholomew, Blaine .

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83, 2014, 83 :671-696

[7]

RNA-seq of the aging brain in the short-lived fish N-furzeri - conserved pathways and novel genes associated with neurogenesis [J].

Baumgart, Mario ;

Groth, Marco ;

Priebe, Steffen ;

Savino, Aurora ;

Testa, Giovanna ;

Dix, Andreas ;

Ripa, Roberto ;

Spallotta, Francesco ;

Gaetano, Carlo ;

Ori, Michela ;

Tozzini, Eva Terzibasi ;

Guthke, Reinhard ;

Platzer, Matthias ;

Cellerino, Alessandro .

AGING CELL, 2014, 13 (06) :965-974

[8]

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging [J].

Beerman, Isabel ;

Bock, Christoph ;

Garrison, Brian S. ;

Smith, Zachary D. ;

Gu, Hongcang ;

Meissner, Alexander ;

Rossi, Derrick J. .

CELL STEM CELL, 2013, 12 (04) :413-425

[9]

Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1 [J].

Bellet, Marina M. ;

Nakahata, Yasukazu ;

Boudjelal, Mohamed ;

Watts, Emma ;

Mossakowska, Danuta E. ;

Edwards, Kenneth A. ;

Cervantes, Marlene ;

Astarita, Giuseppe ;

Loh, Christine ;

Ellis, James L. ;

Vlasuk, George P. ;

Sassone-Corsi, Paolo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (09) :3333-3338

[10]

H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency [J].

Benayoun, Berenice A. ;

Pollina, Elizabeth A. ;

Ucar, Duygu ;

Mahmoudi, Salah ;

Karra, Kalpana ;

Wong, Edith D. ;

Devarajan, Keerthana ;

Daugherty, Aaron C. ;

Kundaje, Anshul B. ;

Mancini, Elena ;

Hitz, Benjamin C. ;

Gupta, Rakhi ;

Rando, Thomas A. ;

Baker, Julie C. ;

Snyder, Michael P. ;

Cherry, J. Michael ;

Brunet, Anne .

CELL, 2014, 158 (03) :673-688

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