Bioactivity profiling using HPLC/microtiter-plate analysis:: Application to a New Zealand marine alga-derived fungus, Gliocladium sp.

被引：50

作者：

Lang, G

Mitova, MI

Ellis, G

Van der Sar, S

Phipps, RK

Blunt, JW

Cummings, NJ

Cole, ALJ

Munro, MHG

机构：

[1] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand

[2] Univ Canterbury, Sch Biol Sci, Christchurch 1, New Zealand

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 04期

关键词：

D O I：

10.1021/np0504917

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Using HPLC/microtiter-plate-based generation of activity profiles the extract of a marine alga-derived fungus, identified as Gliocladium sp., was shown to contain the known strongly cytotoxic metabolite 4-keto-clonostachydiol (1) and also clonostachydiol (2) as well as gliotide (3), a new cyclodepsipeptide containing several D-amino acids. The absolute configuration of 1 was elucidated by reduction to 2, and two further oxidized derivatives of clonostachydiol (5, 6) were prepared and evaluated for biological activity.

引用

页码：621 / 624

页数：4

共 18 条

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ALLEY MC, 1988, CANCER RES, V48, P589

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