A lesson from the HIV patient: The immune response is still the bane (or promise) of gene therapy

被引：4

作者：

Koenig, S

机构：

来源：

NATURE MEDICINE | 1996年 / 2卷 / 02期

关键词：

D O I：

10.1038/nm0296-165

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：165 / 167

页数：3

共 18 条

[1]

CHAVIN KD, 1993, J IMMUNOL, V151, P7249

[2] HIGH HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-1 (HTLV-1) SPECIFIC PRECURSOR CYTOTOXIC T-LYMPHOCYTE FREQUENCIES IN PATIENTS WITH HTLV-1 ASSOCIATED NEUROLOGICAL DISEASE [J].

ELOVAARA, I ;

KOENIG, S ;

BREWAH, AY ;

WOODS, RM ;

LEHKY, T ;

JACOBSON, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) :1567-1573

[3]

GREENSTEIN JL, 1995, CYBERCONGRESS TRANSP

[4] RECENT ADVANCES IN THE APPLICATION OF GENE-THERAPY TO HUMAN-DISEASE [J].

HANANIA, EG ;

KAVANAGH, J ;

HORTOBAGYI, G ;

GILES, RE ;

CHAMPLIN, R ;

DEISSEROTH, AB .

AMERICAN JOURNAL OF MEDICINE, 1995, 99 (05) :537-552

[5] TRANSFER OF HIV-1-SPECIFIC CYTOTOXIC T-LYMPHOCYTES TO AN AIDS PATIENT LEADS TO SELECTION FOR MUTANT HIV VARIANTS AND SUBSEQUENT DISEASE PROGRESSION [J].

KOENIG, S ;

CONLEY, AJ ;

BREWAH, YA ;

JONES, GM ;

LEATH, S ;

BOOTS, LJ ;

DAVEY, V ;

PANTALEO, G ;

DEMAREST, JF ;

CARTER, C ;

WANNEBO, C ;

YANNELLI, JR ;

ROSENBERG, SA ;

LANE, HC .

NATURE MEDICINE, 1995, 1 (04) :330-336

[6] ENGRAFTMENT OF GENE-MODIFIED UMBILICAL-CORD BLOOD-CELLS IN NEONATES WITH ADENOSINE-DEAMINASE DEFICIENCY [J].

KOHN, DB ;

WEINBERG, KI ;

NOLTA, JA ;

HEISS, LN ;

LENARSKY, C ;

CROOKS, GM ;

HANLEY, ME ;

ANNETT, G ;

BROOKS, JS ;

ELKHOUREIY, A ;

LAWRENCE, K ;

WELLS, S ;

MOEN, RC ;

BASTIAN, J ;

WILLIAMSHERMAN, DE ;

ELDER, M ;

WARA, D ;

BOWEN, T ;

HERSHFIELD, MS ;

MULLEN, CA ;

BLAESE, RM ;

PARKMAN, R .

NATURE MEDICINE, 1995, 1 (10) :1017-1023

[7]

MORRIS RE, 1993, J HEART LUNG TRANSPL, V12, pS275

[8] VACCINE THERAPY USING RGP 160 IN EARLY HIV-INFECTION [J].

REDFIELD, R ;

BIRX, D ;

KETTER, N ;

POLONIS, V ;

JOHNSON, S ;

DAVIS, C ;

SMITH, G ;

OSTER, C ;

BURKE, D .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (08) :1333-1333

[9] T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients [J].

Riddell, SR ;

Elliott, M ;

Lewinsohn, DA ;

Gilbert, MJ ;

Wilson, L ;

Manley, SA ;

Lupton, SD ;

Overell, RW ;

Reynolds, TC ;

Corey, L ;

Greenberg, PD .

NATURE MEDICINE, 1996, 2 (02) :216-223

[10]

ROBERTS MR, 1994, BLOOD, V84, P2878

← 1 2 →