Recent developments in the immunology and biology of Malassezia species

被引：51

作者：

Ashbee, Helen Ruth ^{[1
]}

机构：

[1] Univ Leeds, Fac Biol Sci, Inst Mol & Cellular Biol, Skin Res Ctr, Leeds LS2 9JT, W Yorkshire, England

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2006年 / 47卷 / 01期

关键词：

Malassezia; atopic dermatitis; dendritic cell; keratinocyte; inflammatory response;

D O I：

10.1111/j.1574-695X.2006.00057.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Malassezia spp. are members of the normal cutaneous flora, but are also associated with several cutaneous diseases. Recent studies of the interaction of Malassezia spp. with melanocytes, fibroblasts, keratinocytes and dendritic cells have highlighted their potential to modulate the immune response directed against them. In normal skin they may downregulate the inflammatory response, allowing them to live as commensals. In contrast, in atopic/eczema dermatitis syndrome and psoriasis, they may elicit an inflammatory response that contributes to the maintenance of lesions. Future research may define ways to influence this inflammatory cycle and hence to control or prevent exacerbations of these diseases.

引用

页码：14 / 23

页数：10

共 72 条

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