Citrus Flavanones: What Is Their Role in Cardiovascular Protection?

被引：177

作者：

Chanet, Audrey

Milenkovic, Dragan

Manach, Claudine

Mazur, Andrzej

Morand, Christine ^{[1
]}

机构：

[1] CRNH Auvergne, INRA, UNH, UMR 1019, F-63000 Clermont Ferrand, France

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2012年 / 60卷 / 36期

关键词：

citrus flavanones; cardiovascular protection; vascular function; lipid profile; insulin resistance; inflammation; oxidative stress; CORONARY-HEART-DISEASE; ANTIOXIDANT ENZYME-ACTIVITIES; INDUCED ADHESION MOLECULE; ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; MESSENGER-RNA LEVELS; HEPATOCYTE APO-B; NF-KAPPA-B; ORANGE JUICE; VEGETABLE CONSUMPTION;

D O I：

10.1021/jf300669s

中图分类号：

S [农业科学];

学科分类号：

082806 [农业信息与电气工程];

摘要：

Flavanones, including hesperidin and naringin, are polyphenolic compounds highly and almost exclusively present in citrus. Epidemiological studies reported an inverse relationship between their intake and the risk of cardiovascular diseases. Clinical and experimental data further showed their antihypertensive, lipid-lowering, insulin-sensitizing, antioxidative, and anti-inflammatory properties, which could explain their antiatherogenic action in animal models. Although flavanones may be promising compounds that are particularly active in cardiovascular disease prevention, clinical data are still scarce and most in vitro data have been obtained under nonphysiologically relevant conditions. Moreover, the mechanisms responsible for flavanone action are not fully elucidated. Therefore, further research is needed to better evaluate and understand the protective effects of flavanones in cardiovascular diseases.

引用

页码：8809 / 8822

页数：14

共 110 条

[1]

Inhibition of microsomal triglyceride transfer protein expression and apolipoprotein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation of the mitogen-activated protein kinase pathway in hepatocytes [J].