Alkaloids from the roots of Zanthoxylum nitidum and their antiviral and antifungal effects

被引：77

作者：

Yang, Guohong ^{[1
]}

Chen, Daofeng ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200032, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2008年 / 5卷 / 09期

关键词：

D O I：

10.1002/cbdv.200890160

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five alkaloids, 5,6-dihydro-6-methodynitidine (1), dictamnine (2), gamma-fagarine (3), skimmianine (4). and 5-methoxydictamnine (5). were isolated from the roots of Zanthoxylum nitidum. Their structures and configurations were elucidated by spectroscopic methods and X-ray analysis. Compounds 1, 4, and 5 showed in vitro antiviral effect against hepatitis B virus, and compounds 2, 3, and 5 demonstrated marked antimitotic and antifungal activity.

引用

页码：1718 / 1722

页数：5

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