Metabolic syndrome after laparoscopic bariatric surgery

Background Metabolic syndrome (MS) is common among morbidly obese patients undergoing bariatric surgery. The aim of this study was to assess the impact and predictors of bariatric surgery on the resolution of MS. Methods Subjects included 286 patients [age 44.0 +/- 11.5, female 78.2%, BMI 48.7 +/- 9.4, waist circumference 139 +/- 20 cm, AST 23.5 +/- 14.9, ALT 30.0 +/- 20.1, type 2 diabetes mellitus (DM) 30.1% and MS 39.2%] who underwent bariatric surgery. Results Of the entire cohort, 27.3% underwent malabsorptive surgery, 55.9% underwent restrictive surgery, and 16.8% had combination restrictive-malabsorptive surgery. Mean weight loss was 33.7 +/- 20.1 kg after restrictive surgery (follow up period 298 +/- 271 days), 39.4 +/- 22.9 kg after malabsorptive surgery (follow-up period 306 +/- 290 days), and 28.3 +/- 14.1 kg after combination surgery (follow-up period 281 +/- 239 days). Regardless of the type of bariatric surgery, significant improvements were noted in MS (p values from < 0.0001-0.01) as well as its components such as DM (p values from < 0.0001-0.0005), waist circumference (p values < 0.0001), BMI (p values < 0.0001), fasting serum triglycerides (p values < 0.0001 to 0.001), and fasting serum glucose (p values < 0.0001). Additionally, a significant improvement in AST/ALT ratio (p value=0.0002) was noted in those undergoing restrictive surgery. Multivariate analysis showed that patients who underwent malabsorptive bariatric procedures experienced a significantly greater percent excess weight loss than patients who underwent restrictive procedures (p value=0.0451). Percent excess weight loss increased with longer postoperative follow-up (p value < 0.0001). Conclusions Weight loss after bariatric surgery is associated with a significant improvement in MS and other metabolic factors.